Research Topic

Emerging receptors as new targets in health and diseases

About this Research Topic

Transmembrane receptors (such as G protein-coupled receptors (GPCRs), ion channels, tyrosine kinase receptors, cytokine receptors, etc) are major players in the sensing and transmission of information. They are involved in virtually every physiological function and the alteration of their signaling can lead to physiological disturbances and ultimately cause or predispose to disease. The functions of more and more orphan or atypical receptors are being revealed, and unsuspected modes of action of canonical receptors are brought to light, adding unexpected facets of receptor signaling in physiology and pathophysiology.

During the “9th annual meeting of the GDR-3545 GPCR-2020 – from physiology to drugs” held as Worldwide Live Remote Conference from November 6 to 9, 2020, more than 600 experts from around the world—academic, and industrial players—will discuss the latest trends in the field of Signaling, Neurobiology and Metabolism/Microbiota in relation to G protein-coupled receptors.

This special issue of Frontiers in Endocrinology welcomes submissions (original articles, comments, reviews) of all participating labs of this International Congress that are of relevance to novel concepts and discoveries on receptors, such as GPCRs but also receptors from other transmembrane receptor families, in health and disease.

Contributions from other labs are very much welcome.
Potential contributions are invited in, but not limited to, the following fields:
- Interaction of receptors with microbiota/metabolism
- Receptor-mediated signaling of metabolites
- Orphan and atypical receptors
- Non-canonical signaling pathways in health and disease (compartmentalization, biased signaling, newly identified signaling pathways…)
- Novel approaches to study receptor functions in health and disease


Keywords: microbiota, metabolites, GPCR, signaling


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Transmembrane receptors (such as G protein-coupled receptors (GPCRs), ion channels, tyrosine kinase receptors, cytokine receptors, etc) are major players in the sensing and transmission of information. They are involved in virtually every physiological function and the alteration of their signaling can lead to physiological disturbances and ultimately cause or predispose to disease. The functions of more and more orphan or atypical receptors are being revealed, and unsuspected modes of action of canonical receptors are brought to light, adding unexpected facets of receptor signaling in physiology and pathophysiology.

During the “9th annual meeting of the GDR-3545 GPCR-2020 – from physiology to drugs” held as Worldwide Live Remote Conference from November 6 to 9, 2020, more than 600 experts from around the world—academic, and industrial players—will discuss the latest trends in the field of Signaling, Neurobiology and Metabolism/Microbiota in relation to G protein-coupled receptors.

This special issue of Frontiers in Endocrinology welcomes submissions (original articles, comments, reviews) of all participating labs of this International Congress that are of relevance to novel concepts and discoveries on receptors, such as GPCRs but also receptors from other transmembrane receptor families, in health and disease.

Contributions from other labs are very much welcome.
Potential contributions are invited in, but not limited to, the following fields:
- Interaction of receptors with microbiota/metabolism
- Receptor-mediated signaling of metabolites
- Orphan and atypical receptors
- Non-canonical signaling pathways in health and disease (compartmentalization, biased signaling, newly identified signaling pathways…)
- Novel approaches to study receptor functions in health and disease


Keywords: microbiota, metabolites, GPCR, signaling


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

15 January 2021 Abstract
30 June 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

15 January 2021 Abstract
30 June 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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