About this Research Topic
Obesity is associated with adverse metabolic diseases, including cardiovascular disease (CVD) and chronic kidney disease (CKD). These obesity-related diseases were believed to be highly associated with excess fat accumulation in adipose tissue. However, emerging evidence has shown that body fat distribution plays a more important role in body metabolism and obesity-related metabolic diseases, compared with fat accumulation itself. Previous studies have focused mainly on classical visceral adipose tissue and subcutaneous adipose tissue. However, other adipose tissues around vessels, including perivascular adipose, perirenal adipose tissues, and epicardial tissues, have attracted much attention recently. This adipose tissue dysfunction has shown to be associated with a higher risk of CVD and CKD in obesity and metabolic syndrome. However, little is known about the mechanisms underlying this potential association. Hence, studies on the relationship of various adipose tissue dysfunction to metabolism-related diseases are of utmost importance. Understanding the pathobiology and pathophysiology of adipose dysfunction in CVD or CKD will also shed light on potential diagnostic and therapeutic strategies of CVD or CKD targeting adipose tissue.
In this Research Topic, we seek to provide a forum for recent advances on various adipose tissues and adipokines function to identify major contributors of the adipose-vascular axis to obesity and metabolism-related diseases, especially CVD and CKD. We welcome all investigators in the field to submit their Original Research articles (basic and clinical studies), Reviews, and Perspectives. Potential topics include but are not limited to the following:
• Molecular and cellular pathobiology and pathophysiology of adipose dysfunction in CVD or CKD.
• Novel diagnostic and treatment strategies for CVD or CKD targeting adipose tissue
• Emerging roles for adipose tissue in cardiovascular diseases, including arteriosclerosis and thrombosis
Keywords: Adipose, White Adipose Tissue, Brown Adipose Tissue, Perivascular Adipose Tissue, Epicardial Adipose Tissue, Perirenal Adipose Tissue, Adipocytes, Adipokines, Oxidative Stress, Inflammation, Obesity, Insulin Resistance, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Disease, Chronic Kidney Disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.