About this Research Topic
The goal of this Research Topic is to advance our understanding of the neural mechanisms by which a “stereotypical” neural circuit generates behavioral variability. This question has been traditionally addressed under multiple frameworks including motivation, internal states, learning, and plasticity. This Research Topic specifically aims to address genetic, epigenetic, developmental, and physiological mechanisms that reconcile perceived stereotypy of circuit structure and behavioral variability. Robust discussions on the very concept of “stereotypy” and “variability” of both circuit and behavior (including behavioral idiosyncrasy, or a “habit” of an individual) will be an important foundation for achieving this goal, since these words can be used for either individual- or group-level behaviors, without clear quantitative definitions. Additionally, comparative approaches that reveal the evolutionary mechanisms generating diverse behavioral patterns among related species can provide useful insight. Through original experimental and theoretical research, as well as reviews on recent research progress, we aim to highlight specific research areas focused on discovering how diverse neural mechanisms underlie the flexibility of behavior across and within animal species.
We are specifically soliciting Original Research articles and Reviews that:
· Refine the working definitions of “stereotypy” and “variability” in circuits and behavior, and how these concepts should be incorporated into neuroscience research.
· Address molecular and physiological mechanisms that enable flexible behavioral outputs from a “stereotyped” neural circuit.
· Investigate the origins of behavioral polymorphism in an animal population with a relatively “homogeneous” genetic composition. The population of interest includes a laboratory animal colony with a known genetic background and a natural population under genetic equilibrium.
· Shed lights on the evolutionary basis by which species with similar genetic and circuit organizations diversify behavioral patterns. GWAS and other purely correlational studies are outside the scope of this Research Topic.
· Address how the nervous system uses experience and internal states to optimize behavior. Disease models are outside the scope of this Research Topic.
· Investigate, through theory and/or experiments, how behavioral variability can be beneficial for individuals and species.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.