Research Topic

Molecular Mechanisms of Alzheimer’s Disease: From Top to Bottom

About this Research Topic

This Research Topic proposes to explore the molecular mechanisms involved in Alzheimer’s disease, a neurodegenerative disease whose main risk factor is aging. Alzheimer's disease is a global public health priority, and no curative treatments are available until now. The histopathological hallmarks of the disease are the deposition of the β-amyloid peptide in the extracellular space (senile plaques) and the intracellular aggregation of the tau protein in the form of filaments (neurofibrillary tangles) in the brains of affected individuals. The presence of these brain lesions accompanies the loss of calcium homeostasis, dysfunction in the release and uptake of neurotransmitters, and extensive oxidative stress, which jointly contribute to progressive memory loss and cognitive decline in Alzheimer's disease.

The knowledge about the molecular mechanisms implicated in Alzheimer's is essential to design effective treatments and thus counteract the enormous global impact of this type of dementia. Although several strategies to treat Alzheimer's disease have been proposed, the lack of curative treatment stands for the urgent need to understand the molecular mechanisms involved in this disease. Therefore, new studies that range from in vivo, including animal or human models, to in vitro level, including primary cultures or cell lines, are required to cover Alzheimer's disease's knowledge from top to bottom.

The purpose of this Research Topic is to highlight new aspects related to Alzheimer's disease pathological mechanisms, but it is not limited to that. We are also interested in new insights about the already described molecular mechanisms involved in this dementia. Additionally, we are interested in further exploring the development of the disease, since the symptoms manifest much later than the molecular mechanisms which underlie them. Research addressing the development of interventions to improve patients' health, prevent and/or treat Alzheimer's disease, addressing their mechanisms of action are also in the scope of this Research Topic.

We welcome submissions that address various issues on this topic, including (but not limited to) the following:
• Amyloid-beta peptide pathology;
• Loss of calcium homeostasis;
• Inflammation and risk factors
• Cholinergic hypothesis;
• Biomarkers of aging;
• Oxidative stress and redox dysregulation;
• Genetics and epigenetics;
• Neuroprotection and therapeutic strategies applied to Alzheimer's Disease.


Keywords: dementia, oxidative stress, amyloid-beta peptide, inflammation, Alzheimer's disease


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

This Research Topic proposes to explore the molecular mechanisms involved in Alzheimer’s disease, a neurodegenerative disease whose main risk factor is aging. Alzheimer's disease is a global public health priority, and no curative treatments are available until now. The histopathological hallmarks of the disease are the deposition of the β-amyloid peptide in the extracellular space (senile plaques) and the intracellular aggregation of the tau protein in the form of filaments (neurofibrillary tangles) in the brains of affected individuals. The presence of these brain lesions accompanies the loss of calcium homeostasis, dysfunction in the release and uptake of neurotransmitters, and extensive oxidative stress, which jointly contribute to progressive memory loss and cognitive decline in Alzheimer's disease.

The knowledge about the molecular mechanisms implicated in Alzheimer's is essential to design effective treatments and thus counteract the enormous global impact of this type of dementia. Although several strategies to treat Alzheimer's disease have been proposed, the lack of curative treatment stands for the urgent need to understand the molecular mechanisms involved in this disease. Therefore, new studies that range from in vivo, including animal or human models, to in vitro level, including primary cultures or cell lines, are required to cover Alzheimer's disease's knowledge from top to bottom.

The purpose of this Research Topic is to highlight new aspects related to Alzheimer's disease pathological mechanisms, but it is not limited to that. We are also interested in new insights about the already described molecular mechanisms involved in this dementia. Additionally, we are interested in further exploring the development of the disease, since the symptoms manifest much later than the molecular mechanisms which underlie them. Research addressing the development of interventions to improve patients' health, prevent and/or treat Alzheimer's disease, addressing their mechanisms of action are also in the scope of this Research Topic.

We welcome submissions that address various issues on this topic, including (but not limited to) the following:
• Amyloid-beta peptide pathology;
• Loss of calcium homeostasis;
• Inflammation and risk factors
• Cholinergic hypothesis;
• Biomarkers of aging;
• Oxidative stress and redox dysregulation;
• Genetics and epigenetics;
• Neuroprotection and therapeutic strategies applied to Alzheimer's Disease.


Keywords: dementia, oxidative stress, amyloid-beta peptide, inflammation, Alzheimer's disease


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

09 January 2021 Abstract
09 May 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

09 January 2021 Abstract
09 May 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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