Research Topic

Common and Distinct Mechanisms of Migraine and Stroke

About this Research Topic

Migraine is one of the most common neurological disorders, affecting up to 15% of the general population equating to one billion affected individuals worldwide. Despite its prevalence, the underlying pathological mechanisms are largely unknown. Moreover, in many cases the associated pain remains intractable. Likewise, stroke, the loss of brain function due to disrupted blood flow, causes a massive burden on the life of affected individuals. Approximately 5 million people die annually from stroke, while the same number amount of patients are left permanently disabled and many of these patients suffer from headaches. There is a strong link between stroke and migraine, especially migraine with aura as both disorders are associated with the phenomenon of cortical spreading depolarization (often called ‘peri-infarct depolarization’). The subsequent neuroinflammation and oxidative stress likely contribute to exaggeration of both pathologies. The hypercoagulable state may play a promoting role both in migraine and stroke. The concept of the ‘stroke-migraine depolarization continuum’ (Dreier and Reiffurth, 2015) is further supported by evidence on brain microlesions in migraine and a phenomenon called ‘Migrainous Infarction’. There is also an unresolved issue of post-stroke headache, which also links both disorders.

This Research Topic is devoted to the shared and distinct mechanisms underlying migraine and stroke. The comparative study of cellular and molecular mechanisms of migraine and stroke should advance our understanding of their complex nature and yield new pharmaceutical targets for both disorders. We welcome submissions of original research articles and review papers addressing, but not limited to, the following subtopics:

• CSD mechanisms, triggers, propagation, cellular/network impact
• Cortical spreading depolarization (CSD) in migraine and peri-infarct depolarizations (PID) in stroke: what is common?
• Preconditioning for brain tolerance and activation of neurogenesis by CSD.
• A mechanistic rationale for management of the ischemic penumbra.
• Migraine and stroke: are there shared genetic factors?
• Genetic mouse models of stroke and migraine: what did we learn?
• Brain-on-a-chip: a novel avenue for research on migraine and stroke?
• Neuroinflammation and immune responses in migraine and stroke.
• Clotting disturbances in migraine and stroke.
• Mechanisms of Covid19 induced neurological symptoms, stroke and headache.
• Homocysteine as a link between migraine with aura and ischemic stroke
• Role of glial cells in migraine and stroke.
• Oxidative stress in migraine and stroke.
• Headache after stroke: what are the mechanisms?
• Disrupted BBB integrity in migraine and stroke?
• Gender-dependence of migraine and stroke.
• Cellular and molecular mechanisms of ‘Migrainous Infarction’ and microlesions in migraine.
• Repurposing of perspective anti-migraine drugs for stroke and vice versa, any perspective, any risks?


Keywords: Migraine, stroke, neuron, spreading depression, headache


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Migraine is one of the most common neurological disorders, affecting up to 15% of the general population equating to one billion affected individuals worldwide. Despite its prevalence, the underlying pathological mechanisms are largely unknown. Moreover, in many cases the associated pain remains intractable. Likewise, stroke, the loss of brain function due to disrupted blood flow, causes a massive burden on the life of affected individuals. Approximately 5 million people die annually from stroke, while the same number amount of patients are left permanently disabled and many of these patients suffer from headaches. There is a strong link between stroke and migraine, especially migraine with aura as both disorders are associated with the phenomenon of cortical spreading depolarization (often called ‘peri-infarct depolarization’). The subsequent neuroinflammation and oxidative stress likely contribute to exaggeration of both pathologies. The hypercoagulable state may play a promoting role both in migraine and stroke. The concept of the ‘stroke-migraine depolarization continuum’ (Dreier and Reiffurth, 2015) is further supported by evidence on brain microlesions in migraine and a phenomenon called ‘Migrainous Infarction’. There is also an unresolved issue of post-stroke headache, which also links both disorders.

This Research Topic is devoted to the shared and distinct mechanisms underlying migraine and stroke. The comparative study of cellular and molecular mechanisms of migraine and stroke should advance our understanding of their complex nature and yield new pharmaceutical targets for both disorders. We welcome submissions of original research articles and review papers addressing, but not limited to, the following subtopics:

• CSD mechanisms, triggers, propagation, cellular/network impact
• Cortical spreading depolarization (CSD) in migraine and peri-infarct depolarizations (PID) in stroke: what is common?
• Preconditioning for brain tolerance and activation of neurogenesis by CSD.
• A mechanistic rationale for management of the ischemic penumbra.
• Migraine and stroke: are there shared genetic factors?
• Genetic mouse models of stroke and migraine: what did we learn?
• Brain-on-a-chip: a novel avenue for research on migraine and stroke?
• Neuroinflammation and immune responses in migraine and stroke.
• Clotting disturbances in migraine and stroke.
• Mechanisms of Covid19 induced neurological symptoms, stroke and headache.
• Homocysteine as a link between migraine with aura and ischemic stroke
• Role of glial cells in migraine and stroke.
• Oxidative stress in migraine and stroke.
• Headache after stroke: what are the mechanisms?
• Disrupted BBB integrity in migraine and stroke?
• Gender-dependence of migraine and stroke.
• Cellular and molecular mechanisms of ‘Migrainous Infarction’ and microlesions in migraine.
• Repurposing of perspective anti-migraine drugs for stroke and vice versa, any perspective, any risks?


Keywords: Migraine, stroke, neuron, spreading depression, headache


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

15 February 2021 Abstract
15 June 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

15 February 2021 Abstract
15 June 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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