About this Research Topic
The utilization of OMICS technologies in sport science has helped create a deeper understanding of the molecular changes associated with athletes’ training and physical performance. Genomics, proteomics, and metabolomics studies of athletes have revealed changes in their physiological and pathophysiological status, with implications on their general health and performance. Genome-wide association studies combined with expression studies of genes (eQTL), proteins (pQTL), and metabolites (mQTL) in response to exercise could significantly improve our understanding of the underlying molecular changes associated with training. Among these, studies investigating secreted growth factors (secretomics) and hormones (steroidomics) in elite athletes are of great interest to anti-doping research and sports physiology. Together these studies would shed light on the molecular pathways associated with exercise and potentially point to novel biomarkers of intake/effect, with implications not only to athletes, but also to the general population.
OMICS studies in exercise and sport physiology and pathophysiology remain limited. In this Research Topic, we invite authors to submit their original research investigating genomics, proteomics, metabolomics, and secretomics of athletes in health and disease. The goal is to increase our understanding of the underlying molecular pathways associated with exercise physiology and pathophysiology and to identify novel predictive biomarkers and potential therapeutic targets that could help improve athletes’ performance and health, and reduce sports-related injuries. The goal is also to help improve anti-doping tests by gathering a deeper understanding of the endogenous changes in hormones and growth factors in response to exercise, and as a consequence of the use of prohibited substances and methods.
We welcome submissions covering the following areas:
• Integrated OMICS in sport physiology and pathophysiology
• Molecular changes associated with exercise
• Predictive biomarkers associated with improved athletic performance
• Predictive biomarkers of sports-related risk on athletes’ health and injuries
• Investigation of changes in hormones and growth factors for improved understanding of anti-doping tests
• Identification of novel biomarkers for the improved detection of different forms of doping in sport
• Novel statistical/modelling approaches for omics data integration, interpretation and doping detection
Keywords: Sports OMICS, Sports Genomics, Sports Proteomics, Sports Metabolomics, Sports Secretomics, Steroidomics, Biomarkers of Sport physiology, Biomarkers of sports pathophysiology, Biomarkers of doping, Systems Sport Medicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.