About this Research Topic
Gut microbiota has a great impact on human health and is also considered the causes of many endocrine diseases. With the help of sequencing techniques, we gain an inside look at the microorganisms, including the species and contents, etc. However, it still remains a great challenge to understand how the influence works. Some metabolites (or peptides) which can pass through the gut barrier freely are considered as the signal messengers or executive molecules. Some act as ‘functional readout’ that provides the status information of gut flora. Some are important signal molecules and reseasons the occurrence and development of diseases by regulating the signal pathways. Some modulate or take part in host metabolisms and some are even pathogens. Endocrine diseases are complex disorders that occur and development engage interactions of factors at different levels (e.g. host and microbial metabolites, circulating proteins).
The goal of this topic is to identify the origin of some endogenous metabolites and find out those generated/regulated by gut flora. And the functional annotations of these metabolites are also of concern, especially those acting as signal molecular or key ligands. Such studies may help to understand the possible reasons for the occurrence of endocrine disorders. Furthermore, the role of gut microbiota in the regulation of circulating metabolites and proteins has been proposed – yet all converge on influencing endocrine function. These results are expected to further uncover more associations between the gut microbiome and endocrine system, which may be druggable and thus modulated to the benefit of the host.
The aim of the current Research Topic is to discover the possible relationships between endogenous metabolites and gut microbiota, and develop novel molecules that take part in the signal pathway from gut to the body in endocrine diseases. Articles types including original research, reviews, perspectives are acceptable for this topic. Areas to be covered in this Research Topic may include, but are not limited to:
· The metabolic changes caused by the abnormal state of gut flora during endocrine diseases.
· Discovery of gut microbiota-related metabolite biomarkers for the diagnosis\prognosis of endocrine diseases.
· Determine novel signal molecules taking part in the signal pathway of endocrine diseases.
· The metabolic pathway regulated by gut flora originated molecular during endocrine diseases.
· Introduction of gut flora related molecular during endocrine diseases.
· Functional study of metabolites/peptides during the occurrence and development of endocrine diseases.
Keywords: Metabolism, gut microbiota, metabolite, biomarker
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