Aging is a complex physiological process in which a variety of an organism’s systems become dysregulated. Notable among these is the immune system. Aging is associated with a general decrease in adaptive immune function (immunosenescence) which impairs vaccine and anti-pathogen responses. Additionally, advanced age is also associated with an overactive innate immune system, leading to increased basal inflammation (inflammaging) that underlies many age-related chronic diseases.
Nutritional strategies have long been utilized to combat various disease processes. Within recent years, a number of laboratories globally have investigated the impacts of both broad nutritional patterns (Mediterranean diet, ketogenic diet, intermittent fasting, etc.) and specific nutritional compounds on the regulation of immune and vaccine responses. Additionally, nutritional regulation of inflammation and the microbiome has been of tremendous interest. Finally, nutrient- and metabolite-mediated immune cell metabolism (immunometabolism) has been a recent area of active investigation, as has an investigation into the anti-senescence properties of natural products such as quercetin.
The aim of this Research Topic is to bring together new research in the intersection of immunity, nutrition, and metabolism, especially as these pertain to aging. Additionally, up-to-date literature surveys and perspectives on important translational advances in immunonutrition are needed. We encourage the submission of Original Research articles, as well as Reviews, Mini-Reviews, and Perspectives covering the following or related topics:
1. Nutritional strategies to counteract aging-related immune dysfunction
2. Nutraceuticals, dietary supplements, inflammaging, and immunity
3. Nutrition as an adjuvant to vaccine responses
4. Aging and the microbiome
5. Immunometabolism and mitochondrial dysfunction
6. Senolytic properties of dietary components
7. Basic studies in aging and immune function, immunosenescence, and inflammaging
Aging is a complex physiological process in which a variety of an organism’s systems become dysregulated. Notable among these is the immune system. Aging is associated with a general decrease in adaptive immune function (immunosenescence) which impairs vaccine and anti-pathogen responses. Additionally, advanced age is also associated with an overactive innate immune system, leading to increased basal inflammation (inflammaging) that underlies many age-related chronic diseases.
Nutritional strategies have long been utilized to combat various disease processes. Within recent years, a number of laboratories globally have investigated the impacts of both broad nutritional patterns (Mediterranean diet, ketogenic diet, intermittent fasting, etc.) and specific nutritional compounds on the regulation of immune and vaccine responses. Additionally, nutritional regulation of inflammation and the microbiome has been of tremendous interest. Finally, nutrient- and metabolite-mediated immune cell metabolism (immunometabolism) has been a recent area of active investigation, as has an investigation into the anti-senescence properties of natural products such as quercetin.
The aim of this Research Topic is to bring together new research in the intersection of immunity, nutrition, and metabolism, especially as these pertain to aging. Additionally, up-to-date literature surveys and perspectives on important translational advances in immunonutrition are needed. We encourage the submission of Original Research articles, as well as Reviews, Mini-Reviews, and Perspectives covering the following or related topics:
1. Nutritional strategies to counteract aging-related immune dysfunction
2. Nutraceuticals, dietary supplements, inflammaging, and immunity
3. Nutrition as an adjuvant to vaccine responses
4. Aging and the microbiome
5. Immunometabolism and mitochondrial dysfunction
6. Senolytic properties of dietary components
7. Basic studies in aging and immune function, immunosenescence, and inflammaging
