Research Topic

New Therapeutic Approaches Against Inflammation and Immune Regulation in Metabolic Related Diseases

About this Research Topic

Metabolic-related diseases include obesity, metabolic syndrome, diabetes, fatty liver, cardiovascular disease, and related tumors, which are rapidly increasing in prevalence. Metabolic-related diseases accompanied by chronic low-grade inflammation have fundamentally changed our view of the underlying causes ...

Metabolic-related diseases include obesity, metabolic syndrome, diabetes, fatty liver, cardiovascular disease, and related tumors, which are rapidly increasing in prevalence. Metabolic-related diseases accompanied by chronic low-grade inflammation have fundamentally changed our view of the underlying causes and progression of them. Inflammation contributes to maladaptive responses such as fibrosis and necrosis that can cause significant tissue damage. It is the activation of these inflammatory cytokines that play a critical role in the development of a chronic inflammatory state and contributes to metabolic dysfunction. Indeed, several clinical therapeutic strategies that tried to interfere with pro-inflammatory processes have already achieved varying degrees of success. In addition to inflammation, immune regulation has been delineated as a driving force of pathogenesis in metabolic disease. Many emerging studies indicate that innate and adaptive immune cell responses in adipose tissue, as well as in the intestine have critical roles in the regulation of metabolic homeostasis. Immune cells, such as macrophages, T cells, and B cells could promote insulin resistance in metabolic related diseases, in part through secretion of proinflammatory cytokines.

Since inflammation and immune regulation contribute to metabolic-related diseases' pathogenic mechanisms, new therapeutic strategies and combination or multi-target directed therapies may be a new frontier for the treatment of metabolic-related diseases.

The goal of this Special Issue is to understand the relationship between inflammation and immune regulation in the onset and/or progression of the metabolic-related disease and to explore new therapeutic strategies including single and multitarget-directed ligands approach. Original research and review articles are welcome.

Potential topics include but are not limited to the following:
1. Clinical research´╝Ü
- Identification of new biomarkers for metabolic-related diseases in patients
- Construction of early predictive or warning models for metabolic diseases based on inflammation/immune factors.
2. The latest single-cell sequencing research on metabolic-related diseases.
3. Target mechanism research:
- The role of inflammation in metabolic related diseases
- The role of immune regulation and its interaction with inflammation in metabolic-related diseases
- Design, synthesis and in vitro assessment of multitarget-directed ligands or combination therapy for the treatment of immune response and inflammation in metabolic-related disease
- In vivo evaluation of multitarget-directed ligands or combination therapy for the treatment of immune response and inflammation in metabolic-related disease


Keywords: inflammation, immunity, cardiovascular diseases, NAFLD, Diabetes, metabolic dysfunction, cancer, tumour


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

26 May 2021 Manuscript
25 June 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

26 May 2021 Manuscript
25 June 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..