Research Topic

Metabolic Flexibility

About this Research Topic

Metabolic flexibility has been defined as the ability of cells to oxidize substrates for energy production based on the nutrient availability and energy requirement to adjust for metabolic demand, such to sustain a dynamic balance between fuel sources, during alternation of fasting/feeding, variation of meal ...

Metabolic flexibility has been defined as the ability of cells to oxidize substrates for energy production based on the nutrient availability and energy requirement to adjust for metabolic demand, such to sustain a dynamic balance between fuel sources, during alternation of fasting/feeding, variation of meal composition, periods of physical activity or environment modifications. Metabolic flexibility is proposed to be impaired in obesity and chronic diseases such as type 2 diabetes mellitus, cardiovascular diseases, and metabolic syndrome and is now considered as a key determinant of cardiometabolic health.

Today, the mechanisms of the dysregulation of such flexibility and the identification of involved lifestyle and metabolic factors, which ultimately will lead to metabolic inflexibility, are still investigated as they could provide relevant triggers for understanding of the development of metabolic diseases and targeted nutritional prevention and care strategies.

Moreover, the definition and the characterization (from cellular to body level) of metabolic flexibility, as well as standardized assessment methodologies are still discussed, in order to better capture its dynamic and integrative features.

This Research Topic aims to further enhance our understanding of the concept of metabolic flexibility, to refine its assessment methodologies and of its importance in the development and management of metabolic diseases and associated conditions.

We welcome Original Research articles including randomized and non-randomized clinical trials, as well as cross-sectional studies, Narrative and Systematic Reviews, Perspectives, and Opinions.

This Research Topic welcomes papers dealing with the concept of metabolic flexibility on themes such as, but not limited to:
• Definitions and estimates of metabolic flexibility
• Methodologies for metabolic flexibility assessment at the cellular, tissue and body level (in vitro, physiological conditions, modeling, etc…)
• Interplay between these processes in the subcutaneous adipose tissue
• Effects of lifestyle interventions (including lifestyle modifications such as diet and/or exercise, physical activity, sedentary behavior) on metabolic flexibility
• Metabolic flexibility and organs interplay including microbiome
• Prediction of metabolic flexibility
• Genetics and metabolic flexibility
• Adipose tissue expandability and fuel selection
• Metabolic inflexibility and glucolipotoxicity
• Epigenetics of metabolic flexibility
• Metabolic flexibility and mitochondrial function
• Determinant factors of metabolic flexibility
• Metabolic flexibility and intracellular nutrient overload
• Gender differences and metabolic flexibility
• Nutrient sensing and metabolic flexibility
• Organelle dynamics and metabolic flexibility


Keywords: Metabolic Flexibility, Phenotyping, Lifestyle, Nutrients, Dynamic, Nutritional Challenges, Exercise, Adipose Tissue, Skeletal Muscle


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

20 July 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

20 July 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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