Research Topic

Metabolic Related Cardiomyopathy in Hyperglycemic Patients

About this Research Topic

Indeed, metabolic-related cardiomyopathy is a large spectrum of functional and structural myocardial dysfunctions encompassing heart failure with preserved ejection fraction (HFpEF) and coronary heart diseases without angioplasty procedure evidence of coronary lesions. As all, such conditions have common ...

Indeed, metabolic-related cardiomyopathy is a large spectrum of functional and structural myocardial dysfunctions encompassing heart failure with preserved ejection fraction (HFpEF) and coronary heart diseases without angioplasty procedure evidence of coronary lesions. As all, such conditions have common hyperglycemia-mediated physiopathologic pathways made up by: a) myocardial tissue inflammation, b) enhanced oxidative stress, c) impaired trans-membrane ion fluxes, d) declined myocardial wall elasticity.

One can also not exclude that heart failure with reduced ejection fraction (HErEF) might be just a worsening effect over the time of a progression of HFPEF due to: a) an unappropriated therapy (such as undertreatment per se or inaccuracy of the drug/s used); b) impaired microvascular circulation with a further worsening of the ventricular wall contraction power and secondary decline in stroke volume.

Understanding the interplay between metabolic disturbances and inflammatory processes, which underlies the pathogenesis of metabolic-related cardiomyopathy, is clinically relevant to improve diagnosis, management and consequently minimize the current unacceptably high mortality rates. Both inflammation and metabolism interact over the course of cardiomyopathy progression, and likely impact its treatment and prevention. Despite metabolic diseases being an important aetiology of cardiomyopathy, there are few dedicated pieces of research that aim to understand the etiologic-specific diagnosis and clinical management of this syndrome. Today, it is known that progressive pathologic changes in cardiac metabolism may precede myocardial dysfunction, indicating that metabolic remodelling is an important early event in the progression of cardiomyopathy. Consequently, the identification of metabolic abnormalities may be able to prevent or ameliorate disease progression.

Moreover, hyperglycemic patients can form proteins alteration resulting from their glycosylation in presence of high glucose concentrations that can be converted in stable covalent adducts called advanced glycosylation end products (AGEs). AGEs can influence the development of cardiovascular complications associated with hyperglycemia. AGE prevention is emerging as a novel therapeutic intervention for the treatment of cardiovascular complications such as acute myocardial infarction in the presence of hyperglycemia.


Thus, our guest edition would provide further insights: to better understand and support the causal, mechanistic role of metabolic inflammation, including hyperglycemia-mediated physio-pathologic pathways, in the development of metabolic related cardiomyopathy; to propose a framework that shows how metabolic comorbidities profoundly impact cardiac metabolism and inflammatory pathways; to provide clinical evidence for the best diagnosis and clinical management of metabolic related cardiomyopathy.

Manuscript can be original article, literature or systematic review, and meta-analysis.


Keywords: Metabolic related cardiomyopathy, metabolic inflammation, clinical management, cardiac metabolism, hyperglycaemia-mediated physio-pathologic pathways


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

31 July 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

31 July 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..