Advances on Pathogenesis and Treatment of Lower Urinary Tract Symptoms and Pelvic Floor Dysfunction Diseases

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First Affiliated Hospital of Wenzhou Medical University

The Second Hospital of Shandong University

Guiming Liu, MD, PhD

Northeast Ohio Medical University

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Lower urinary tract symptoms (LUTS) and pelvic floor dysfunction diseases are very common in the population. For example, 20% of men over age 50 have different degrees of prostatic hyperplasia, which can cause bladder voiding problems, and 40% of women over age 40 have pelvic floor related problems, such as urinary incontinence or other lower urinary tract dysfunctions. While LUTS can affect individuals of any age, the risk of developing these conditions increases with advanced age. With the aging of the population worldwide, these problems become more and more prominent. With the development of the study on LUTS, more effective treatment options continue to emerge, but it still lacks an effective way to relieve LUTS among some specific conditions, and the pathophysiologic mechanism still remains unknown.

For this Research Topic, we would like to bring together recent studies including both basic and clinical research on lower urinary tract symptoms (LUTS) and pelvic floor dysfunction, focusing on lower urinary tract functional rehabilitation, pharmaceutical treatment, cell therapy, neuromodulation, and regulation, etc., to promote the prevention and treatment of LUTS. Understanding the physiological and pathological basis of the lower urinary tract and pelvic floor function and disorders is also very important to shed light on new prevention and treatment approaches. We welcome submissions of Original Research and Review articles focusing on but not limited to the following aspects:

• Physiological and pathological mechanisms of urinary continence
• Study of local, peripheral nerve regulating dysfunction on overactive bladder, neurogenic bladder, or interstitial cystitis/bladder pain syndrome
• New technology or approach on urodynamic study or bladder function assessment
• Peripheral nerve regulation of lower urinary tract and pelvic floor dysfunction
• Restoring or replacing bladder or urethral structure/function
• Research or review on the mechanisms of lower urinary tract physiology and pathology

Lower urinary tract symptoms (LUTS) and pelvic floor dysfunction diseases are very common in the population. For example, 20% of men over age 50 have different degrees of prostatic hyperplasia, which can cause bladder voiding problems, and 40% of women over age 40 have pelvic floor related problems, such as urinary incontinence or other lower urinary tract dysfunctions. While LUTS can affect individuals of any age, the risk of developing these conditions increases with advanced age. With the aging of the population worldwide, these problems become more and more prominent. With the development of the study on LUTS, more effective treatment options continue to emerge, but it still lacks an effective way to relieve LUTS among some specific conditions, and the pathophysiologic mechanism still remains unknown.

For this Research Topic, we would like to bring together recent studies including both basic and clinical research on lower urinary tract symptoms (LUTS) and pelvic floor dysfunction, focusing on lower urinary tract functional rehabilitation, pharmaceutical treatment, cell therapy, neuromodulation, and regulation, etc., to promote the prevention and treatment of LUTS. Understanding the physiological and pathological basis of the lower urinary tract and pelvic floor function and disorders is also very important to shed light on new prevention and treatment approaches. We welcome submissions of Original Research and Review articles focusing on but not limited to the following aspects:

• Physiological and pathological mechanisms of urinary continence
• Study of local, peripheral nerve regulating dysfunction on overactive bladder, neurogenic bladder, or interstitial cystitis/bladder pain syndrome
• New technology or approach on urodynamic study or bladder function assessment
• Peripheral nerve regulation of lower urinary tract and pelvic floor dysfunction
• Restoring or replacing bladder or urethral structure/function
• Research or review on the mechanisms of lower urinary tract physiology and pathology

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Editors

First Affiliated Hospital of Wenzhou Medical University

The Second Hospital of Shandong University

Guiming Liu, MD, PhD

Northeast Ohio Medical University

Impact

118,902 Total views

95,966 Article views

21,332 Article downloads

1,604 Topic views

Published In

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Frontiers in Surgery

Genitourinary Surgery and Interventions

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Frontiers in Physiology

Integrative Physiology

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Frontiers in Medicine

Geriatric Medicine

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