About this Research Topic
The oral cavity is an open environment and has a complex microbiota which induces sophisticated host-microbe interactions. Disproportionate host responses and microbiota dysbiosis are the major etiological factors of oral biofilm induced inflammatory diseases characterized by tissue inflammation and destruction. The relationship between shifts of microbiome, changes of inflammatory conditions and disease progression has been investigated over decades but still remains to be further clarified.
This Research Topic will discuss several important questions about the impact of inflammation on the oral microbiome in oral biofilm induced inflammatory diseases. What drives the shift from the localized and contained inflammatory response to progressive and destructive inflammatory response? When and how does the microbiome become dysbiotic? Is the microbiome shift associated with inflammatory response or spontaneous evolution? Is the microbiome shift an initiator or consequence of disease? What is the temporal relationship between the dysbiotic microbiome and the innate and acquired immune response?
We welcome the following:
- Clinical studies investigating how inflammation affects microbiome in oral diseases
- In vitro or in vivo studies investigating the interactions between the immune response and microbiota and/or the temporal relationship between dysbiosis and changes of inflammation in oral diseases
- Reviews of the associations and interactions between inflammation and oral microbiome in oral diseases
Dr. Van Dyke is inventor on several granted and pending licensed and unlicensed patents awarded to the Forsyth Institute that are subject to consulting fees and royalty payments. He is a founder of Nocendra, Inc. and AIAH Inc. He also holds grant awards from the NIDCR and several corporations in the area of inflammatory disease prevention and treatment, including periodontal diseases. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Host Microbial Interactions, Inflammation, Microbiome, Mouth Diseases, Oral Health
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