Epilepsy is a common neurological disease that is characterized by recurrent seizures and affects nearly 1% of the world's population. Uncontrolled epileptic seizures would severely affect patients’ life quality and may even result in an unexpected death.
Classical anti-epileptic drugs (AED) which target either membrane ion channels or neural transmissions have been wildly used to control seizures. However, the high incidence of pharmacoresistance, narrow therapeutic index, and unwanted side-effects caused by taking long-term AEDs raise substantial concern. There is an urgent need for developing novel medications or treatments for epilepsy.
With a deeper understanding of the cellular and molecular mechanisms of epileptogenesis, non-classical novel anti-epileptic targets, such as neurosteroids, neuroinflammatory molecules and cannabinoids shed a light on finding a new approach to treat epilepsy, which is not only controlling seizures but also retarding epileptogenesis. Further investigations based on the novel epileptogenesis are essential for the discovery and development of promising new treatment approaches.
This Research Topic focuses on investigating the novel mechanism of epileptogenesis and the novel pharmaceutical treatment approaches inspired by non-traditional molecular mechanisms. We welcome all Original Research articles and Review submissions on, but not limited to, the following themes:
• Study novel cellular and molecular mechanism of epileptogenesis which has potential pharmacological translational significance.
• Investigating potential novel pharmacological approaches that target novel non-classical anti-epileptic targets, such as neurosteroids, neuroinflammatory molecules, cannabinoids, for treating epilepsy.
Epilepsy is a common neurological disease that is characterized by recurrent seizures and affects nearly 1% of the world's population. Uncontrolled epileptic seizures would severely affect patients’ life quality and may even result in an unexpected death.
Classical anti-epileptic drugs (AED) which target either membrane ion channels or neural transmissions have been wildly used to control seizures. However, the high incidence of pharmacoresistance, narrow therapeutic index, and unwanted side-effects caused by taking long-term AEDs raise substantial concern. There is an urgent need for developing novel medications or treatments for epilepsy.
With a deeper understanding of the cellular and molecular mechanisms of epileptogenesis, non-classical novel anti-epileptic targets, such as neurosteroids, neuroinflammatory molecules and cannabinoids shed a light on finding a new approach to treat epilepsy, which is not only controlling seizures but also retarding epileptogenesis. Further investigations based on the novel epileptogenesis are essential for the discovery and development of promising new treatment approaches.
This Research Topic focuses on investigating the novel mechanism of epileptogenesis and the novel pharmaceutical treatment approaches inspired by non-traditional molecular mechanisms. We welcome all Original Research articles and Review submissions on, but not limited to, the following themes:
• Study novel cellular and molecular mechanism of epileptogenesis which has potential pharmacological translational significance.
• Investigating potential novel pharmacological approaches that target novel non-classical anti-epileptic targets, such as neurosteroids, neuroinflammatory molecules, cannabinoids, for treating epilepsy.