About this Research Topic
Ageing is inevitable, and several structural and functional changes occur in the body with advanced ageing. Aging has becoming a remarkable public health issue worldwide: by 2050, the proportion of the world's population over 60 years will reach 22%. This increase in the number of populations aging calls for attention to aging-associated diseases, including neurodegeneration disorders such as Alzheimer’s and Parkinson’s.
In the brain, different cell types, including neurons, astrocytes, oligodendrocytes, as well as microglia, respond to aging differently. Studying the transcriptome changes in different cell types during aging, and identification of cell type-specific aging markers would enable us to move the therapeutic window to earlier stages of aging-associated disease progression/premature aging. In addition, understanding the mechanism of how cell-type specific aging genes are involved in the aging process could further shed light on the prevention and therapy of the aging-related diseases.
Our aim is to give a reader the most up-to-date perspective on how the interaction between genes and neuropsychological processes leads to neurological disorders in normal aging and minor and major neurocognitive disorders. We welcome contributions from clinicians, neuroscientists, and academics. It is intended to provide an opportunity for researchers of different perspectives to discuss recent progress in this field.
The present article collection aims at covering from basic research to clinical various neuropathological studies, to instigate novel approaches to understand, diagnose and treat different kind of neuropsychiatric disorders.
We encourage submission of original empirical research articles. Furthermore, the call is open for theoretical approaches such as Reviews, Perspective, and Opinion articles on promising future directions. This Research Topic is widely open to contributions that target the following topics:
1-Hallmarks of CNS aging (genetic factors, epigenetic signatures, telomeres,…)
2-Detection of specific cell type aging marker genes
3-Finding the overlaps of aging altered genes with Alzheimer’s disease samples.
4-Quantifying changes of different cell types in aging (e.g., microglia, astrocytes, neurons and oligodendrocytes).
5-Finding possible changes in molecular pathways in aging (e.g., signalling pathways, inflammation, alternative splicing)
6-Exploring novel cell markers that have altered expression in brain aging and Alzheimer’s disease
7-Quantifying the number of specific cell types in aging.
8-In-depth analysis of the changes in alternative splicing in aging brain such as a comparison with additional external expression datasets (e.g., RNA-Seq, from the Gene Expression Omnibus).
9-Review and perspective articles that discuss recent advances, potential contexts of use and future perspectives of genetic biomarkers
10-Animal models for studying aging and genes interplay
Keywords: Aging, Neurodegeneration, Central Nervous System, Genes, Basic research
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.