About this Research Topic
Obesity is a worldwide disease characterized by adipose tissue expansion associated with metabolic dysfunction and chronic low-grade inflammation. Different inflammatory mediators are released during this process, such as pro-inflammatory cytokines (TNF, IL-6, IL-1β) with a consequent reduction of those anti-inflammatory (adiponectin, IL-10). The onset of this inflammation is precocious, which indicates that a "meta-inflammation" is also a physiological response that occurs during weight gain aiming to restore metabolic and energy homeostasis. However, once the consumption of a high-calorie diet and/or excessive fat and sugar intake goes on, the inflammation is overwhelmed, triggering chronic low-grade inflammation. Adipose tissue remodeling generally maintains the tissue's health, but in obesity, it gets out of control and leads to adipocyte necrosis in association with the recruitment and activation of macrophages and systemic insulin resistance. This response is then associated with the development of comorbidities such as cardiovascular diseases, type 2 diabetes, fatty liver, and some types of cancer.
In this Research Topic, we will aim to discuss the pathophysiological aspects of inflammation during the development of obesity. On one side, the importance of a balanced inflammation to control adipose tissue expansion and appropriately maintain metabolic pathways' homeostasis. On the other side, the exceeded features of this inflammation process that overloads the system, leading to obesity's dysfunctions. The pathophysiological studies highlighting the molecules and inflammatory pathways that may protect or worsen the metabolic and endocrine systems will help advance in preventive or therapeutic actions to fight against the increasing rates of obesity worldwide.
Authors are welcome to submit Original Research and Review articles on topics including but not limited to:
1. Role of mediators of inflammation on metabolic control
2. Role of mediators of inflammation on adipocyte development and function
3. Effect of nutrients (e.g., amino acids, glucose, fructose, lipids) on inflammatory pathways
4. Impact of nutrients in the adipose tissue remodeling trigger by inflammation
5. Functional food as a strategy to treat meta-inflammation
6. Influence of acute and chronic inflammatory diseases on modulating inflammation and metabolic alterations in obesity
7. The importance of nutrients in the treatment of obesity
8. Effect of microbiota in the regulation of meta-inflammation
9. Inflammation in adipose tissue browning
10. Effect of exercise on adipose tissue inflammation
11. Diet and inflammation in adipose tissue aging
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.