The global burden of different human malignancies is a potential health crisis due to increased rate of incidence and mortality rate. Although significant advances have been made over the past few decades, our knowledge of understanding the molecular basis of carcinogenesis and emerging cancer immunotherapy still remains very much limited to certain type of malignancies. Mutual interactions of tumor cells with immune cells, especially myeloid cells, have been shown to be associated with diverse clinical outcomes in different human cancers. Therefore, an in-depth understanding of basic molecular mechanisms of tumor and myeloid cells interaction may provide the opportunities to uncover the complex heterogeneity with in the different tumor mass. Moreover, it will also help to overcome the acquired resistivity to different types of existing chemotherapies and immunotherapies.
Currently, limited information is available on the modulation of immune tumor microenvironment (iTME) that can address a higher incidence and aggressiveness of certain types of human cancers. The main objective of this Research Topic is to explore the different molecular mechanisms associated with onset, progression and metastasis of different human cancers with particular interest around role of myeloid cells. Besides, this Research Topic will also cover the potential role of different molecular signaling mechanism in modulating the iTME. Research studies addressing the potential role of different molecular targets linked with carcinogenesis and adaptive resistance are welcomed for submission under this Research Topic. Furthermore, the studies involving the functional role of myeloid cells and how combinatorial immunotherapies could be successfully employ to inhibit the tumor progression and metastasis are welcome. Review articles exploring the detailed molecular mechanism of carcinogenesis and recapitulate the emerging cancer immunotherapies or novel techniques are also encouraged.
The areas covered in this Research Topic include the following:
• Inflammation mediated molecular mechanism of carcinogenesis and metastasis
• Role of DNA damage response and inflammation in enrichment of cancer stem cells associated with drug resistivity and immune suppression
• Potential and novel role of myeloid cells such as myeloid derived suppressor cells and tumor associated macrophages in cancer progression and metastasis
• Exosome biology and single cell analysis to explore the paracrine interaction of cancer and myeloid cells
• Role of microbiome in modulation of inflammation and iTME
• Contribution of obesity-associated inflammation in cancer progression and metastasis
• Impact of miRNA biology in regulating the inflammation regulated iTME
The global burden of different human malignancies is a potential health crisis due to increased rate of incidence and mortality rate. Although significant advances have been made over the past few decades, our knowledge of understanding the molecular basis of carcinogenesis and emerging cancer immunotherapy still remains very much limited to certain type of malignancies. Mutual interactions of tumor cells with immune cells, especially myeloid cells, have been shown to be associated with diverse clinical outcomes in different human cancers. Therefore, an in-depth understanding of basic molecular mechanisms of tumor and myeloid cells interaction may provide the opportunities to uncover the complex heterogeneity with in the different tumor mass. Moreover, it will also help to overcome the acquired resistivity to different types of existing chemotherapies and immunotherapies.
Currently, limited information is available on the modulation of immune tumor microenvironment (iTME) that can address a higher incidence and aggressiveness of certain types of human cancers. The main objective of this Research Topic is to explore the different molecular mechanisms associated with onset, progression and metastasis of different human cancers with particular interest around role of myeloid cells. Besides, this Research Topic will also cover the potential role of different molecular signaling mechanism in modulating the iTME. Research studies addressing the potential role of different molecular targets linked with carcinogenesis and adaptive resistance are welcomed for submission under this Research Topic. Furthermore, the studies involving the functional role of myeloid cells and how combinatorial immunotherapies could be successfully employ to inhibit the tumor progression and metastasis are welcome. Review articles exploring the detailed molecular mechanism of carcinogenesis and recapitulate the emerging cancer immunotherapies or novel techniques are also encouraged.
The areas covered in this Research Topic include the following:
• Inflammation mediated molecular mechanism of carcinogenesis and metastasis
• Role of DNA damage response and inflammation in enrichment of cancer stem cells associated with drug resistivity and immune suppression
• Potential and novel role of myeloid cells such as myeloid derived suppressor cells and tumor associated macrophages in cancer progression and metastasis
• Exosome biology and single cell analysis to explore the paracrine interaction of cancer and myeloid cells
• Role of microbiome in modulation of inflammation and iTME
• Contribution of obesity-associated inflammation in cancer progression and metastasis
• Impact of miRNA biology in regulating the inflammation regulated iTME