About this Research Topic
Personalized medicine - or precision medicine - aims to establish a new treatment approach based on each patient’s individual profile. This approach is especially relevant for complex traits, that arise as combinations of genetic and environmental factors. Psychological traits and psychiatric disorders belong to this category and are conditions associated with a high emotional burden for patients and their families. Additionally, they carry an extreme financial burden. Consequently, considering all the factors mentioned above, personalized medicine efforts were highly focused on those aspects in the last century. Given their high complexity, our understanding is still far from complete and the application of the results is still not well established. Nevertheless, progress is now emerging and there is an urgent need to translate genetic information for the benefit of patients.
As mentioned before, translating genetic information into clinical settings is of special interest in patients with mental illness. This Research Topic will focus on studies that aim to take part in advancing personalized treatment efforts to reach the final goal and to use genetic information in the clinical environment. The importance of this topic lies in several factors, as it can:
• simplify drug development, testing, and registration process while reducing the costs in the pharmaceutical industry;
• relieve emotional and financial burden;
• be of significant help to patients and their families.
Genome-wide association studies (GWAS) and candidate gene studies are the two types of genetic association studies that can identify biomarkers that explain the inter-individual genetic variability between individuals. In recent years, many GWAS and candidate gene studies found genetic variants that can explain some of this variability; however, most findings are not yet clinically actionable. More studies are needed to confirm previous findings and identify new targets.
This Research Topic will focus on personalized treatment in mental illness. The final aim is to reach one step closer to translate genetic information into clinically actionable findings. Therefore, we welcome submissions that address the following fields/topics:
• discussions on possible tools (e.g., genetic counseling, molecular genetic studies, gene discovery, etc.) that may help to reach this goal;
• candidate gene studies and GWAS to identify genetic biomarkers;
• case reports on genetic counseling;
• socioeconomic factors in mental illness treatment; potential genetic testing.
This Research Topic welcomes the following article types: Original Research, Brief Research Report, Review, Mini Review, Systematic Review, Clinical Trials, and Case Report.
Keywords: Genetics, pharmacogenetics, personalized treatment, clinical settings, psychopathology, genetic counselling, genetic testing
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.