About this Research Topic
Despite many emerging approaches becoming available for metabolomics data and high-throughput sequencing data to infer metabolic and epigenetic regulations, it remains challenging to establish the multi-level interactions between metabolic regulation and epigenetic factors. Moreover, the causal relationships among nutrition, epigenetics and complex phenotypic traits are to be further investigated. Therefore, the aims of this Research Topic are 1) to collect research data that uses cutting-edge approaches to study the metabolic and epigenetic crosstalk at a cellular and organismal level, 2) to understand the molecular mechanisms underlying epigenetic reprogramming mediated by metabolic switch in physiology and pathology, 3) to manipulate favorable epigenetic elements to improve metabolic disorders, and 4) to facilitate research efforts in the area of knowledge creation and disease management.
We welcome Original Research articles, Methods, Data Reports, Reviews, Mini-Reviews, and Systematic Reviews to submit to this Research Topic. Here are some specific themes we would like contributors to address:
1) Crosstalk between metabolites and epigenetic marks (histone modifications, DNA methylation, epigenetic machineries post-translational modifications) and their biological function
2) Metabolites and nutrition – induced epigenetic changes in development and disease
3) Technological development for measuring axis of metabolism and epigenetics programing
4) Epigenetic alterations and their implications on metabolic reprogramming of cancer and stem cells
Keywords: Metabolites, histone marks, DNA methylation, metabolic reprogramming, epigenetic reprogramming, signaling pathways, development, disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.