Cardiovascular diseases (CVDs) are the leading cause of death in the United States, accounting for nearly one in every seven deaths. Due to the high number of patients and high-cost treatment, CVDs also represent a serious financial burden. CVDs include various disorders affecting the heart and vessels: coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, congenital heart disease, deep vein thrombosis, and pulmonary embolism.
Currently, there are very limited efficient conventional pharmacological or surgical approaches, to treat the heart in cardiovascular diseases. Over the last decade, there are many reports on the beneficial effects of stem cell / gene therapy to enhance the myocardial function in disease conditions. In contrast to currently applied treatments, these strategies have the potential to stimulate and support endogenous mechanisms of different cardiac cells and thus provide the basis for improved heart function.
This Research Topic aims to highlight the different types strategies used to treat the dysfunctional heart in a diseased state, especially in cardiovascular diseases and its underlying molecular mechanism. We envisage that submitted articles might investigate the new methodologies used at the level of genes, small molecules, long noncoding RNA, mRNAs and exosomes used to treat the heart in cardiovascular diseases. We welcome any type of article such as basic science reports, translational research, clinical studies, reviews and methodology papers.
Cardiovascular diseases (CVDs) are the leading cause of death in the United States, accounting for nearly one in every seven deaths. Due to the high number of patients and high-cost treatment, CVDs also represent a serious financial burden. CVDs include various disorders affecting the heart and vessels: coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, congenital heart disease, deep vein thrombosis, and pulmonary embolism.
Currently, there are very limited efficient conventional pharmacological or surgical approaches, to treat the heart in cardiovascular diseases. Over the last decade, there are many reports on the beneficial effects of stem cell / gene therapy to enhance the myocardial function in disease conditions. In contrast to currently applied treatments, these strategies have the potential to stimulate and support endogenous mechanisms of different cardiac cells and thus provide the basis for improved heart function.
This Research Topic aims to highlight the different types strategies used to treat the dysfunctional heart in a diseased state, especially in cardiovascular diseases and its underlying molecular mechanism. We envisage that submitted articles might investigate the new methodologies used at the level of genes, small molecules, long noncoding RNA, mRNAs and exosomes used to treat the heart in cardiovascular diseases. We welcome any type of article such as basic science reports, translational research, clinical studies, reviews and methodology papers.
