Research Topic

Host-adapted metabolism and its regulation in Bacterial Pathogens

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Here we investigate how bacterial pathogens adapt their metabolism during colonisation of host organisms, how the metabolism of pathogenic bacteria and host organism is interconnected and which mechanisms of control are active. ...

Here we investigate how bacterial pathogens adapt their metabolism during colonisation of host organisms, how the metabolism of pathogenic bacteria and host organism is interconnected and which mechanisms of control are active.
As a basis for this investigation, different chapters identify metabolic pathways that are important for the bacteria during infection and to determine the metabolic fluxes. The metabolic reactions of the host organisms and the genetic mechanisms of metabolic adaptation are partly unraveled.
Questions we consider include: Why are bacteria able to multiply in the body of the host and can cause disease? Which specific toxines and/or invasines are produced? In general, which metabolic adaptations allow bacterial pathogens to colonize their host? Further points we will consider concern the interconnected metabolism of host and pathogen and which regulatory mechanisms are activated in pathogen and host. We will furthermore consider high sensitive methods of bioanalytics and high throughput screening developed in recent years. For the first time a systematic synopsis of bacterial pathogen metabolism to host conditions is possible.
Further chapters will consider main metabolic pathways and fluxes, metabolic reactions including the host as well as genetic and regulatory mechanisms of metabolic adaptation. We want to achieve an integrated picture of the host- and pathogen adaptation of metabolism during infection, a bioanalytical characterization of the relevant metabolic pathways as well as insights on the genetic mechanisms of metabolic adaptations and their cross-links to virulence-relevant regulons.


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