About this Research Topic
A more rational use of expensive treatment drugs together with actions to minimize patient toxic events and its consequences would dramatically reduce medical costs, as an added benefit.
Pharmacogenomics is an emerging field focused on genetic variations relevant to drug action. The idea is that solid data about allele variants, haplotypes and their effects on gene expression, applied to the (dynamics of) chemotherapy regimens’ design and dosing, will prevent undertreatment while avoiding associated toxicity in patients. Some of the potential polymorphic target genes include CYP isozymes, transferases, dehydrogenases, deaminases, reductases, ABC transporters, drug receptors and DNA repair enzymes.
With this Research Topic we would like to present an updated overview of the current trends in the experimental genetic approaches worldwide and discuss future directions in cancer pharmacotherapy. Thus, we encourage authors to submit original experimental research work, regular and systematic reviews, opinion letters, and methods of modeling and simulation of pharmacotherapeutic response to cancer treatment with molecular approaches.
In summary, we strongly believe that this Research Topic could be a powerful tool for better understanding genetic basis of individual differences in patient’s response to antineoplastic drugs. The main scope of this issue is to gather evidence to conceive chemotherapy for clinical practice as a “tailor-made-suit” for each patient.
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