About this Research Topic
Burkholderia pseudomallei and B. mallei, causes melioidosis and glanders, respectively, which are two endemic infectious diseases in many parts of the world. The recent reports of glanders outbreaks in horses in Pakistan and Bahrain and the increasing incidence of human melioidosis in Thailand and other tropical regions have resulted in increased research efforts to prevent these diseases. Moreover, both B. mallei and B. pseudomallei exhibit an intriguing intracellular life cycle including the induction of actin tail formation and cell fusion and thereby have developed as model organisms in infection biology.
This Research Topic summarizes recent progress to understand these pathogens at the molecular level, with emphasis in their virulence traits, host pathogen interactions, population structure and potential targets for therapeutic intervention and vaccine development.
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