About this Research Topic
Recent large trials question the impact of percutaneous coronary interventions in improving patients´ prognosis, such that there is a growing need for methods that assess more precisely which patients and lesions deserve intervention. Methods for the invasive or non-invasive assessment of coronary physiology are well established in clinical routine, and their use is steadily expanding. However, a number of questions still remain. These pertain, among many other, the relative merits of hyperemia-based versus resting indexes, the relationship with imaging methods, the impact of post-PCI hemodynamics, scenarios of complex anatomies (e.g. tandem or diffuse stenosis), the role of the microcirculation, the best strategies to treat microvascular dysfunction, the impact of non-invasive or less-invasive technologies and of medical or interventional therapies on coronary hemodynamics. This research topic welcomes original research, reviews, clinical case reports which provide address the above mentioned questions.
Keywords: fractional flow reserve, coronary microcirculation, resting indexes, quantitative flow reserve, intracoronary imaging
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