About this Research Topic
The complex physiology of eukaryotic cells is regulated through numerous mechanisms, such as epigenetics and posttranslational modifications to name a few. The wide-ranging diversity of these mechanisms constitutes a way of dynamically regulating the functionality, activity, and subcellular localization of proteins, as well as modulating the differential expression of relevant genes that is dependent upon external and internal stimuli tallowing an organism to adapt accordingly. Up until now, there has been a growing awareness that dysregulation of epigenetics and posttranslational modifications does play a significant role in many types of diseases, especially in cancer, and this has fueled more research to focus on drug discovery. Nevertheless, only a select few number of studies have actually moved into human clinical trials.
While epigenetics and posttranslational modifications are hot topics in cancer research, only several small compounds have been approved to be tested by clinical trials. Many questions and underlying mechanisms still remain unanswered and unclear, especially when it comes to the cross talk among these epigenetics and posttranslational modifications, the identification of novel compound backbones for these targeting drugs, the biological function of epigenetics and posttranslational modifications in metabolism, cancer targeting immunotherapies, drug resistance, phase change, ferroptosis, and pyroptosis. Hence, further studies that will advance the present understanding of epigenetics and posttranslational modifications and therapeutics targeting them in cancer are very much warranted.
As a fastly growing area of research, the interplay between epigenetics and posttranslational modifications as it relates to cancer drug discovery proves to be quite a promising focus point to discover life-saving therapies. For this Research Topic, we invite authors to submit Original Research and Review articles that provide novel insights into the field of epigenetics and posttranslational modifications and their potential as therapeutic targets in cancer, including but not limited to:
• Epigenetic and posttranslational modification related molecular mechanisms.
• Drug target identification and drug discovery.
• Assay development, molecular modeling and target structure analysis that also include an experimental component ( in vitro or in vivo ).
Keywords: Drug target, Posttranslational modification, Cancer, Therapeutics, Epigenetics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.