The rapid increase in greenhouse gas (GHG) emission due to the extensive use of fossil resources has necessitated the production of renewable energies and chemicals to sustain the current economic activities while realigning the carbon balance. Particularly, the microbial production of biochemicals has provided an attractive route to relieve the current energy crisis and global climate change. In the past, engineering strategies such as random mutagenesis and conventional selection have long been employed for strain development, which is time-consuming and low efficient. In a fast and efficient manner, synthetic biology approaches are poised to revolutionize strain development for biochemical production in several aspects, including design of non-natural biosynthetic pathways, modular pathway assembly, dynamic sensing and regulation, compartmentalization, pathway balancing and rewiring, cofactor engineering as well as high-throughput screening of biological analytes.
The overall goal of this Research Topic is to collect recent advances in the development of microbial cell factories for biochemical production using various synthetic biology approaches. Briefly, this Research Topic will cover any useful and effective strategies for the sustainable and cost-effective production of biochemicals in microbial cell factories. In particular, new findings, new methods, challenges and future perspectives for microbial production of biochemicals will be welcome in this Research Topic. Furthermore, the Topic will cover systems biology strategies that can be applied to elucidate natural biosynthetic pathways or design non-natural biosynthetic pathways for value-added chemicals.
This Research Topic is intended to collect Original Research articles, Methods articles, Reviews, Mini-reviews, Perspective and Opinion articles. We particularly welcome articles on, but not limited to, the following topics:
• Development of synthetic biology and/or CRISPR-based approaches for microbial cell factories
• Design and/or reconstitution of biosynthetic pathways/system through computational tools (including AI) and multi-omics approaches
• Dynamic regulation and the fine-tuning of biosynthetic pathways/networks
• Mining of superior biocatalysts or genetic elements for complex biosynthetic pathways
The rapid increase in greenhouse gas (GHG) emission due to the extensive use of fossil resources has necessitated the production of renewable energies and chemicals to sustain the current economic activities while realigning the carbon balance. Particularly, the microbial production of biochemicals has provided an attractive route to relieve the current energy crisis and global climate change. In the past, engineering strategies such as random mutagenesis and conventional selection have long been employed for strain development, which is time-consuming and low efficient. In a fast and efficient manner, synthetic biology approaches are poised to revolutionize strain development for biochemical production in several aspects, including design of non-natural biosynthetic pathways, modular pathway assembly, dynamic sensing and regulation, compartmentalization, pathway balancing and rewiring, cofactor engineering as well as high-throughput screening of biological analytes.
The overall goal of this Research Topic is to collect recent advances in the development of microbial cell factories for biochemical production using various synthetic biology approaches. Briefly, this Research Topic will cover any useful and effective strategies for the sustainable and cost-effective production of biochemicals in microbial cell factories. In particular, new findings, new methods, challenges and future perspectives for microbial production of biochemicals will be welcome in this Research Topic. Furthermore, the Topic will cover systems biology strategies that can be applied to elucidate natural biosynthetic pathways or design non-natural biosynthetic pathways for value-added chemicals.
This Research Topic is intended to collect Original Research articles, Methods articles, Reviews, Mini-reviews, Perspective and Opinion articles. We particularly welcome articles on, but not limited to, the following topics:
• Development of synthetic biology and/or CRISPR-based approaches for microbial cell factories
• Design and/or reconstitution of biosynthetic pathways/system through computational tools (including AI) and multi-omics approaches
• Dynamic regulation and the fine-tuning of biosynthetic pathways/networks
• Mining of superior biocatalysts or genetic elements for complex biosynthetic pathways