Research Topic

Protein Phosphorylation and Dephosphorylation in Plant-Microbe Interactions

About this Research Topic

Protein phosphorylation and dephosphorylation regulate activities involved in plant-microbe interactions. As the first layer of plant immunity, plasma-membrane localized receptor-like kinases (RLKs) and receptor-like proteins (RLPs) detect the presence of microbe-associated molecular patterns (MAMPs) and trigger intracellular phosphorylation relays such as auto-phosphorylation and cross phosphorylation of RLKs, activation of mitogen-activated protein kinases (MAPKs) and calcium-dependent protein kinases (CPKs). Concurrently, protein phosphatases play an important role in balancing appropriate dynamics in immunity by regulating the duration and amplitude of phosphorylation cascades. 

A successful pathogen secrets effector proteins that interfere with the host phosphorylation cascade either directly or indirectly. Pathogens evolve effectors that can abolish the kinase activities of pattern recognition receptors (PRRs) by dephosphorylation, modification, or degradation. Some effectors are able to inhibit phosphorylation of downstream signaling components further dampening immune responses. Though we already have an overall picture of protein phosphorylation and dephosphorylation in plant-microbe interactions, the detailed molecular mechanism is worth further exploration. 

This Research Topic aims to advance the understanding of protein phosphorylation and dephosphorylation encompassing the entire process of plant-microbe interactions. Studies included in this topic will report the discovery of new host kinases and phosphatases involved in innate immunity and mechanisms of pathogen effectors that manipulate host phosphorylation events. All types of articles are welcome (Original Research, Review, Methods, and Perspective), including but not limited to:

- Novel plant kinases and phosphatases in innate immunity.
- Pathogen kinases and phosphatases that interfere with host phosphorylation events.
- Phospho-omics during any type of host-microbe interaction.
- Molecular mechanisms controlling the duration and amplitude of host phosphorylation events during host-microbe interactions. 

Please note:Studies falling into the categories below will not be considered for review, unless they are expanded and provide functional or mechanistic insights into the biological system or process being studied:

i) Descriptive collection of transcripts, proteins or metabolites, including comparative sets as a result of different conditions or treatments;
ii) Descriptive studies that define gene families using basic phylogenetics and the assignment of cursory functional attributions (e.g. expression profiles, hormone or metabolites levels, promoter analysis, informatic parameters).


Keywords: Kinase, Phosphatase, phosphorylation, host-microbe interactions, MAPK, MAMP, pattern recognition receptors


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Protein phosphorylation and dephosphorylation regulate activities involved in plant-microbe interactions. As the first layer of plant immunity, plasma-membrane localized receptor-like kinases (RLKs) and receptor-like proteins (RLPs) detect the presence of microbe-associated molecular patterns (MAMPs) and trigger intracellular phosphorylation relays such as auto-phosphorylation and cross phosphorylation of RLKs, activation of mitogen-activated protein kinases (MAPKs) and calcium-dependent protein kinases (CPKs). Concurrently, protein phosphatases play an important role in balancing appropriate dynamics in immunity by regulating the duration and amplitude of phosphorylation cascades. 

A successful pathogen secrets effector proteins that interfere with the host phosphorylation cascade either directly or indirectly. Pathogens evolve effectors that can abolish the kinase activities of pattern recognition receptors (PRRs) by dephosphorylation, modification, or degradation. Some effectors are able to inhibit phosphorylation of downstream signaling components further dampening immune responses. Though we already have an overall picture of protein phosphorylation and dephosphorylation in plant-microbe interactions, the detailed molecular mechanism is worth further exploration. 

This Research Topic aims to advance the understanding of protein phosphorylation and dephosphorylation encompassing the entire process of plant-microbe interactions. Studies included in this topic will report the discovery of new host kinases and phosphatases involved in innate immunity and mechanisms of pathogen effectors that manipulate host phosphorylation events. All types of articles are welcome (Original Research, Review, Methods, and Perspective), including but not limited to:

- Novel plant kinases and phosphatases in innate immunity.
- Pathogen kinases and phosphatases that interfere with host phosphorylation events.
- Phospho-omics during any type of host-microbe interaction.
- Molecular mechanisms controlling the duration and amplitude of host phosphorylation events during host-microbe interactions. 

Please note:Studies falling into the categories below will not be considered for review, unless they are expanded and provide functional or mechanistic insights into the biological system or process being studied:

i) Descriptive collection of transcripts, proteins or metabolites, including comparative sets as a result of different conditions or treatments;
ii) Descriptive studies that define gene families using basic phylogenetics and the assignment of cursory functional attributions (e.g. expression profiles, hormone or metabolites levels, promoter analysis, informatic parameters).


Keywords: Kinase, Phosphatase, phosphorylation, host-microbe interactions, MAPK, MAMP, pattern recognition receptors


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

24 May 2021 Abstract
21 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

24 May 2021 Abstract
21 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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