About this Research Topic
Skeletal muscle represents about half of the total human body mass and plays an essential role in posture and locomotion. In addition, skeletal muscle exerts autocrine, paracrine and endocrine effects through the secretion of signaling molecules that are critical regulators of whole-body metabolic homeostasis. Impairment in these crosstalk processes between skeletal muscle and other tissues can result in harmful effects and contribute to the pathophysiology of many different diseases, including cancer, heart failure, and neuromuscular disorders. Elucidating the primary and secondary contributions of muscle-related signaling and the mechanisms underlying skeletal muscle wasting are, therefore, critical steps towards developing novel strategies to improve human health.
We are seeking manuscripts addressing the mechanisms and/or the implications of skeletal muscle crosstalk with other tissues in the body. We aim to publish mainly original articles with data that provide insights into treating diseases. We welcome short communications with novel findings, even if against current paradigms. We also welcome research articles showing challenging outcomes to interpret, in addition to well-controlled studies rejecting or proving the null hypothesis. Articles showing direct interactions between skeletal muscle and other tissues such as liver, heart, bone, adipose tissue and neurons are highly sought after. Finally, publishing studies showing that changes in muscle metabolism can result in more broad systemic effects is likewise a goal of this article collection.
Examples of in-scope papers include 1) the contribution of skeletal muscle to the pathophysiology of non-primarily muscle diseases, including a broad spectrum of chronic degenerative diseases; 2) novel myokines or other molecules linking intracellular muscle biology with other cells; 3) novel mechanisms underlying skeletal muscle wasting and implications for human health; 4) novel data related to non-pharmacological strategies able to improve whole-body metabolism via adaptations occurring in skeletal muscle, including exercise training protocols; 5) novel therapeutic insights to treat muscle genetic diseases.
Please note that abstract submission is not mandatory. Interested individuals and research groups are welcome to submit their manuscript to this Research Topic without submitting an abstract beforehand.
Keywords: Skeletal Muscle, Muscle Wasting, Atrophy, Muscle Physiology, Neuromuscular
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.