Research Topic

The Developing Kidney: Perinatal Aspects and Relevance throughout Life

About this Research Topic

Human perinatal nephrology is a very diverse field in medicine, shared - among others - between obstetricians, neonatologists and nephrologists. Extremely low-birth-weight infants, IUGR babies and term neonates cared for in NICU are predisposed to acute kidney injury and prone to develop progressive renal failure at an early age. Cases with congenital malformations of the kidney and urinary tract (CAKUT) are another specific group. A holistic, systematic, multidisciplinary approach is needed to assess the degree and impact of kidney impairment in these vulnerable infants. 


As there is a wealth of observations that fetal and neonatal renal development is the main driver of short and long-term outcome, we aim to merge expertise, observations and opinions on how clinical research can improve recognition, management (neuroprotection) and subsequent outcome in (pre)term neonates with congenital or acquired renal disorders. Furthermore, the variability in renal development and function should make us explore the impact of preventive or curative interventions.


We welcome systematic reviews as well as original research articles within the domain of perinatal kidney function in at-risk (symptomatic and asymptomatic) newborns, including (directly or indirectly) related subject areas, which may cover, but not be limited to, the following topics:


  • Renal function and perinatal drug exposure
  • Maternal causes of a poor nephron endowment in the neonates
  • Renal physiology and pathophysiology in critically ill neonates
  • Precision medicine and kidney function in neonatology
  • Nephroprotection in LBWI
  • Evolutionary nephrology and preterm birth
  • Early nutrition and renal consequences in preemies
  • Renal follow-up in children born preterm
  • Long-term renal consequences of preterm birth
  • Fetal diagnosis and management
  • Experimental preclinical (animal, ex vitro) that illustrate mechanisms relevant to perinatal nephrology.


Keywords: acute kidney injury, nephron endowment, nephroprotection, long-term renal function, newborn


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Human perinatal nephrology is a very diverse field in medicine, shared - among others - between obstetricians, neonatologists and nephrologists. Extremely low-birth-weight infants, IUGR babies and term neonates cared for in NICU are predisposed to acute kidney injury and prone to develop progressive renal failure at an early age. Cases with congenital malformations of the kidney and urinary tract (CAKUT) are another specific group. A holistic, systematic, multidisciplinary approach is needed to assess the degree and impact of kidney impairment in these vulnerable infants. 


As there is a wealth of observations that fetal and neonatal renal development is the main driver of short and long-term outcome, we aim to merge expertise, observations and opinions on how clinical research can improve recognition, management (neuroprotection) and subsequent outcome in (pre)term neonates with congenital or acquired renal disorders. Furthermore, the variability in renal development and function should make us explore the impact of preventive or curative interventions.


We welcome systematic reviews as well as original research articles within the domain of perinatal kidney function in at-risk (symptomatic and asymptomatic) newborns, including (directly or indirectly) related subject areas, which may cover, but not be limited to, the following topics:


  • Renal function and perinatal drug exposure
  • Maternal causes of a poor nephron endowment in the neonates
  • Renal physiology and pathophysiology in critically ill neonates
  • Precision medicine and kidney function in neonatology
  • Nephroprotection in LBWI
  • Evolutionary nephrology and preterm birth
  • Early nutrition and renal consequences in preemies
  • Renal follow-up in children born preterm
  • Long-term renal consequences of preterm birth
  • Fetal diagnosis and management
  • Experimental preclinical (animal, ex vitro) that illustrate mechanisms relevant to perinatal nephrology.


Keywords: acute kidney injury, nephron endowment, nephroprotection, long-term renal function, newborn


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

28 May 2021 Abstract
25 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

28 May 2021 Abstract
25 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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