Research Topic

Microvascular Dysfunction and Organ Failure During Cardiac Surgery

About this Research Topic

Patients undergoing cardiac surgery with cardiopulmonary bypass are at risk of developing organ failure. The development of organ failure is only in part understood, although it is generally accepted that derangements in the host immune and coagulation responses contribute to its progression. A common factor is a microvascular dysfunction. The vascular endothelium holds a central position in the regulation of fluid transport. Inflammatory mediators activate the endothelium, fueling a proinflammatory host response as well as procoagulant processes. These changes result in shedding of the glycocalyx, endothelial hyperpermeability, vascular leakage, edema formation, and may lead to disturbed microcirculatory perfusion. As microcirculatory perfusion is essential for tissue delivery of oxygen and nutrients, disturbances in microcirculatory perfusion may result in a self-reinforcing process of organ dysfunction.


Microvascular dysfunction is observed in patients undergoing cardiac surgery with cardiopulmonary bypass. Hyperactive inflammatory and coagulation responses disturb microcirculatory perfusion, which subsequently leads to organ failure. This process, leading to organ failure, is aggravated by fluid accumulation in the interstitium, which compresses tissue and impairs microcirculatory perfusion even further. The pathophysiology is however complex and not well understood. The aim of this Research Topic is to highlight the vascular endothelium as a relevant player in the development of organ dysfunction in patients undergoing cardiac surgery. 


We invite investigators to submit original research and review articles including research on patients, animals as well as in vitro studies. The areas of interest include, but are not limited to:


• Endothelial function and injury

• The glycocalyx 

• Microcirculatory perfusion 

• Disturbances of coagulation and platelet function

• The effect of cardiopulmonary bypass and the effect of fluid resuscitation on the above-described conditions

• Interventions targeting the above-described conditions


Keywords: Endothelial function, Cardiac surgery, Cardiopulmonary bypass, Coagulation, Glycocalyx, Microcirculatory perfusion, Organ function


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Patients undergoing cardiac surgery with cardiopulmonary bypass are at risk of developing organ failure. The development of organ failure is only in part understood, although it is generally accepted that derangements in the host immune and coagulation responses contribute to its progression. A common factor is a microvascular dysfunction. The vascular endothelium holds a central position in the regulation of fluid transport. Inflammatory mediators activate the endothelium, fueling a proinflammatory host response as well as procoagulant processes. These changes result in shedding of the glycocalyx, endothelial hyperpermeability, vascular leakage, edema formation, and may lead to disturbed microcirculatory perfusion. As microcirculatory perfusion is essential for tissue delivery of oxygen and nutrients, disturbances in microcirculatory perfusion may result in a self-reinforcing process of organ dysfunction.


Microvascular dysfunction is observed in patients undergoing cardiac surgery with cardiopulmonary bypass. Hyperactive inflammatory and coagulation responses disturb microcirculatory perfusion, which subsequently leads to organ failure. This process, leading to organ failure, is aggravated by fluid accumulation in the interstitium, which compresses tissue and impairs microcirculatory perfusion even further. The pathophysiology is however complex and not well understood. The aim of this Research Topic is to highlight the vascular endothelium as a relevant player in the development of organ dysfunction in patients undergoing cardiac surgery. 


We invite investigators to submit original research and review articles including research on patients, animals as well as in vitro studies. The areas of interest include, but are not limited to:


• Endothelial function and injury

• The glycocalyx 

• Microcirculatory perfusion 

• Disturbances of coagulation and platelet function

• The effect of cardiopulmonary bypass and the effect of fluid resuscitation on the above-described conditions

• Interventions targeting the above-described conditions


Keywords: Endothelial function, Cardiac surgery, Cardiopulmonary bypass, Coagulation, Glycocalyx, Microcirculatory perfusion, Organ function


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 May 2021 Abstract
28 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 May 2021 Abstract
28 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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