Diabetes is the seventh leading cause of death according to the Centers for Disease Control and Prevention (CDC), but mortality due to complications ensuing from chronic diabetes could step it even higher in the ranking category. Long-standing uncontrolled diabetes is known to affect the kidney, heart, cardiovascular system, eyes, and the nervous system. Diabetes increases the incidence of heart attacks and strokes and is the leading cause for kidney failure. Other common diabetic complications include diabetic neuropathy that leads to limb amputations and diabetic retinopathy that can result in blindness.
There is an increasing need to understand the pathological basis of how diabetes affects different organ systems. This information is required to develop therapeutic interventions and effective drug delivery strategies to manage and treat diabetic complications in patients. Novel targets are being identified at the levels of transcription and translation, protein expression and activity, and cell and organ levels.. Targeted drug delivery to achieve maximum efficacy and maintain appropriate drug concentrations is an exciting emerging area for the management and treatment of diabetes and associated complications.
This Research Topic for research and review articles will be focused on the following areas:
1. Novel findings in the pathophysiology of diabetes and related complications
2. Novel targets to treat diabetes-related complications that include, but not limited to, retinopathy, nephropathy, neuropathy, cancer, stroke, and cardiovascular disease, etc.
3. The transcriptomics of high glucose effects on different cell types
4. Novel drug molecules, natural compounds, RNA therapeutics, and gene therapy, etc. to treat diabetic complications.
5. Innovative drug delivery systems for improved efficacy and compliance in the treatment of diabetic complications
Diabetes is the seventh leading cause of death according to the Centers for Disease Control and Prevention (CDC), but mortality due to complications ensuing from chronic diabetes could step it even higher in the ranking category. Long-standing uncontrolled diabetes is known to affect the kidney, heart, cardiovascular system, eyes, and the nervous system. Diabetes increases the incidence of heart attacks and strokes and is the leading cause for kidney failure. Other common diabetic complications include diabetic neuropathy that leads to limb amputations and diabetic retinopathy that can result in blindness.
There is an increasing need to understand the pathological basis of how diabetes affects different organ systems. This information is required to develop therapeutic interventions and effective drug delivery strategies to manage and treat diabetic complications in patients. Novel targets are being identified at the levels of transcription and translation, protein expression and activity, and cell and organ levels.. Targeted drug delivery to achieve maximum efficacy and maintain appropriate drug concentrations is an exciting emerging area for the management and treatment of diabetes and associated complications.
This Research Topic for research and review articles will be focused on the following areas:
1. Novel findings in the pathophysiology of diabetes and related complications
2. Novel targets to treat diabetes-related complications that include, but not limited to, retinopathy, nephropathy, neuropathy, cancer, stroke, and cardiovascular disease, etc.
3. The transcriptomics of high glucose effects on different cell types
4. Novel drug molecules, natural compounds, RNA therapeutics, and gene therapy, etc. to treat diabetic complications.
5. Innovative drug delivery systems for improved efficacy and compliance in the treatment of diabetic complications