Fibrosis is seen in a wide variety of benign and malignant diseases in the digestive systems. Fibrosis develops as the consequences of inflammation, which involves a variety of components such as immune cells, fibroblasts, endothelial cells, cancer cells, mediators, extracellular matrixs and pathogens. The dynamic interaction of these participants determines the nature of fibrosis in quantity and quality, and the fate of fibrosis. Elucidation of the mechanisms of fibrosis progression and regression could lead to the identification of new therapeutic targets to control organ fibrosis. Recently, we have seen the advances in our understanding of cellular and molecular mechanisms responsible for the interplays between inflammation and fibrosis.
The goal of this Research Topic is to update the current knowledge of inflammation-fibrosis interplays in digestive diseases. We would like to clarify the mechanisms how the interplays lead to the development of fibrosis, the roles of interplays in the diseases (promoting or suppressive), the organ- and disease-specific interplays, and how we could control the interplays to treat and prevent the fibrosis.
The scope of this Research Topic is wide and the papers dealing with wide aspects of the inflammation-fibrosis interplays, from basic (in vitro and in vivo), translational, and clinical studies are welcome. Papers which eventually could lead to the application in clinics (biomarkers and treatments) are also welcome.
Fibrosis is seen in a wide variety of benign and malignant diseases in the digestive systems. Fibrosis develops as the consequences of inflammation, which involves a variety of components such as immune cells, fibroblasts, endothelial cells, cancer cells, mediators, extracellular matrixs and pathogens. The dynamic interaction of these participants determines the nature of fibrosis in quantity and quality, and the fate of fibrosis. Elucidation of the mechanisms of fibrosis progression and regression could lead to the identification of new therapeutic targets to control organ fibrosis. Recently, we have seen the advances in our understanding of cellular and molecular mechanisms responsible for the interplays between inflammation and fibrosis.
The goal of this Research Topic is to update the current knowledge of inflammation-fibrosis interplays in digestive diseases. We would like to clarify the mechanisms how the interplays lead to the development of fibrosis, the roles of interplays in the diseases (promoting or suppressive), the organ- and disease-specific interplays, and how we could control the interplays to treat and prevent the fibrosis.
The scope of this Research Topic is wide and the papers dealing with wide aspects of the inflammation-fibrosis interplays, from basic (in vitro and in vivo), translational, and clinical studies are welcome. Papers which eventually could lead to the application in clinics (biomarkers and treatments) are also welcome.