About this Research Topic
Cancer is known to be caused by various environmental factors which transmit intracellular signaling to reduce apoptosis or promote cell cycle for proliferation and invasion. In particular, hormone-receptors play important roles in the development and progression of cancer. Androgen receptor (AR) signals have central roles in prostate cancer progression. This receptor acts as a nuclear receptor (NR) to exert its function by binding to specific genomic sites and regulates the target gene expression. Epigenetic changes including altered DNA methylation, histone modification, and chromatin remodeling are induced upon NR or related oncogenic transcription factors recruitment. In addition, non-coding RNAs such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) also function for promoting the aggressiveness of cancers by modulating various cell signals. Moreover, protein level modifications such as ubiquitylation and phosphorylation were found to be key events in NR and related signals in cancer progression.
Therefore, the aim of this Research Topic is to investigate underlying mechanisms which contribute to the progression of genitourinary and hormone-dependent cancers. Regulation of cell signal transduction at various steps including the epigenetic, transcriptional, post-transcriptional, and post-translational regulation function to enhance the aggressiveness and treatment-resistance of cancers. There is a reciprocal interplay among biochemical signalings which influences cancer hallmarks including migration, metastasis, and angiogenesis. In this context, we also discuss the role of metabolic and epigenetic aberrations and new therapeutic opportunities arising from these changes. Moreover, we will explore new functions of non-coding RNAs in modulating drug sensitivity and resistance in these types of cancers.
This Research Topic focuses on understanding various molecular mechanisms to regulate genitourinary cancers such as renal and prostate cancer. Cell signals by post-translational modification or epigenetic regulation in the cancer genome will be appropriate. Target effects by these transcriptional or non-genomic programs to promote cell proliferation, epithelial-mesenchymal transition, enhance migratory potential and altered metabolism in cancer cells will also be discussed.
We welcome experts in the field to contribute Original Research and Reviews on the various facets of hormone receptor signaling in human cancers for increasing our knowledge, as well as on how clinical data may be exploited as tools in developing anti-cancer therapies and new biomarkers.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: hormone receptor, steroid hormone, epigenetic factor, non-coding RNA, transcription, post-translational regulation, splicing, metastasis, tumor growth, apoptosis, prostate cancer, genitourinal cancer
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