About this Research Topic
In recent years, more and more studies have found synergistic activity between chemo/radio therapy and ICI treatments. It has been discovered that the chemo/radio therapies change the immunosuppressive tumor microenvironment (TME) resulting in improved tumor responses. There is intense interest in using chemo/radio therapy in combination with immunotherapies to augment anti-tumor immune responses and improve treatment outcome.
This Research Topic aims to highlight the emerging role of the TME, discuss potential challenges of therapeutic manipulations of the TME after radio/chemotherapy and review how radio/chemotherapy affects the clinical outcomes of immunotherapies. We welcome the submissions of Original Research, Review, Mini Review, Opinion and Perspective that cover the recent advances made in the TME affected by radio/chemotherapies and immunotherapies, which include but are not limited to:
1. Multiomics analysis of the impact of radiotherapy and/or chemotherapy on the TME;
2. Single-cell sequencing analysis of the impact of radiotherapy and/or chemotherapy on tumor immunity;
3. Screening of diagnostic/therapeutic markers for radiotherapy/chemotherapy combined with immunotherapy;
4. Exploration of the mechanisms underlying functional genomics in immune infiltration;
5. Development of preclinical models that facilitate the research on the genomics of human immunity;
6. Analysis of genetic/epigenetic changes related to the TME after chemotherapy and/or radiotherapy.
Keywords: immune checkpoint inhibitors, immunotherapy, Multiomics, radiotherapy, chemotherapy, single-cell sequencing, genomics, immune infiltration, preclinical models, microenvironment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.