About this Research Topic
The human microbiome consists of fungi, archaea, bacteria, and viruses that colonize various areas of the human organ systems such as digestive, respiratory, skin, and urogenital areas. Our microbiome plays a critical role in our health: it defends us against pathogen, contributes to the development of our immune system, and helps metabolize various compounds. Maintaining a balanced microbiota ecosystem is vital to maintaining our health. Several studies have demonstrated that dysbiosis or alterations in the balance of the microbial populations in a microbiome can significantly alter the host’s homeostasis and are linked to a plethora of health problems.
There exists a dynamic interaction between the microbiome and its human hosts influenced by factors related to the microbiome, the hosts, and the environment. Despite a large increase in research on the human microbiome and rapid advancement of high-throughput, culture-independent technologies that has allowed us to investigate the population structure and genetic potential of our microbiome, we are only beginning to understand how these microbial, host, and environmental factors are shaping the dynamics of the interactions between us and our microbiome and how these interactions, in turn, contribute to our health.
In this special issue, we accept various research studies, ranging from molecular, pre-clinical, and clinical studies, that focus on the interactions between the microbiome and its human host on various organs and organ systems and how these interactions influence our health. Below are some examples of accepted research studies, but not limited to the following:
• Single or multiomics analysis on cellular gene expressions of both microbiomes and cell-lines (or animal models)
• Population analysis of microbiomes on people with inflammatory bowel diseases.
• Analysis of secreted metabolites from microbiome and its effect on people with neuropathological diseases.
• Metagenomics analysis of altered microbiomes in people with Diabetes Mellitus type II with elevated FOS intake.
• Response in patients’ body fat and triglyceride level upon alteration of gut microbiota with probiotic supplementation
• Alteration of the microbial population in certain diseases
Types of eligible research studies include original research articles, research communications, reviews, systematic reviews, mini-reviews, expert opinions, and perspectives.
This Research Topic does not consider descriptive studies that are solely based on amplicon (eg. 16S rRNA) profiles, unless they are accompanied by a clear hypothesis and experimentation and provide insight into the microbiological system or process being studied. Authors are encouraged to submit a statement alongside the manuscript where they specify the methods used to test the hypothesis and how the reported results support and validate this hypothesis.
Keywords: Microbiomes, microbial population, host, diseases, health
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.