Herpesvirus infection of the eye causes a variety of pathologies including, corneal and stromal keratitis, conjuctivitis, corneal ulcers, etc, all of which can lead to permanent vision loss if not intervened. The host-virus interaction that takes place on the ocular surface is of utmost importance given the immune privelge of the eye. Understanding the immunology and pathogenesis affecting the corneal surface during ocular virus infections can help bring novel interventions that can help millions of people around the world who suffer from eye related diseases. This research topic will focus on articles that present original review or research articles that target host-pathogen interactions, immune reaction to infection, disease progression and possible interventions to stop virus replication and inflammation in the eye.
Host pathogen interactions, especially virus-cell interplay on the corneal surface is of great significance. These interactions can result in a myriad of diseases of the eye leading to vision loss in many cases. Understanding the immunology and pathogenesis affecting the corneal surface during ocular virus infections can help bring novel interventions that can help millions of people around the world who suffer from eye related diseases. This research topic will focus on articles that present original review or research articles that target host-pathogen interactions, immune reaction to infection, disease progression and possible interventions to stop virus replication and inflammation in the eye. Specific topics for this special issue include novel ocular patthogenesis caused by viruses, new intracellular pathways that delineate the genesis of viral pathogenesis, new cellular and molecular biology techniques to study viral pathogenesis in the ocular tissue, novel drugs and inhibitors that target previously unknown or untested pathways to suppress viral replication, pathogenesis and spread in the ocular tissue.
The scope of this research topic will be limited to viral infections of the eye. Original Research performed in vitro corneal, retinal and other ocular cell types will be considered. original research performed on ex vivo ocular systems and in vivo will also be considered. Small molecule, peptide and biologic therapeutic interventions that can reduce viral pathogenesis in the eye will also be of interest to this research topic. Finally research conducted on the interplay between the host immune system and viral pathogenesis will also be considered. Authors should focus on the submitting original research or review articles that highlight new or previously unknown or untested cellular and molecular pathways that induce viral pathogenesis in the eye. Authors can also submit articles on the status of various immune pathways that regulate viral replication in the eye. Novel research on how peri ocular tissue including the eye lids, lacrimal gland, trigeminal ganglia is affected by viral infections and their method of action. Authors can also submit manuscripts that detail the efficacy of drugs that are taken systemically or topically to reduce viral replication in eye, reduce post viral inflammation, whether standalone or in combination with existing drugs.
Herpesvirus infection of the eye causes a variety of pathologies including, corneal and stromal keratitis, conjuctivitis, corneal ulcers, etc, all of which can lead to permanent vision loss if not intervened. The host-virus interaction that takes place on the ocular surface is of utmost importance given the immune privelge of the eye. Understanding the immunology and pathogenesis affecting the corneal surface during ocular virus infections can help bring novel interventions that can help millions of people around the world who suffer from eye related diseases. This research topic will focus on articles that present original review or research articles that target host-pathogen interactions, immune reaction to infection, disease progression and possible interventions to stop virus replication and inflammation in the eye.
Host pathogen interactions, especially virus-cell interplay on the corneal surface is of great significance. These interactions can result in a myriad of diseases of the eye leading to vision loss in many cases. Understanding the immunology and pathogenesis affecting the corneal surface during ocular virus infections can help bring novel interventions that can help millions of people around the world who suffer from eye related diseases. This research topic will focus on articles that present original review or research articles that target host-pathogen interactions, immune reaction to infection, disease progression and possible interventions to stop virus replication and inflammation in the eye. Specific topics for this special issue include novel ocular patthogenesis caused by viruses, new intracellular pathways that delineate the genesis of viral pathogenesis, new cellular and molecular biology techniques to study viral pathogenesis in the ocular tissue, novel drugs and inhibitors that target previously unknown or untested pathways to suppress viral replication, pathogenesis and spread in the ocular tissue.
The scope of this research topic will be limited to viral infections of the eye. Original Research performed in vitro corneal, retinal and other ocular cell types will be considered. original research performed on ex vivo ocular systems and in vivo will also be considered. Small molecule, peptide and biologic therapeutic interventions that can reduce viral pathogenesis in the eye will also be of interest to this research topic. Finally research conducted on the interplay between the host immune system and viral pathogenesis will also be considered. Authors should focus on the submitting original research or review articles that highlight new or previously unknown or untested cellular and molecular pathways that induce viral pathogenesis in the eye. Authors can also submit articles on the status of various immune pathways that regulate viral replication in the eye. Novel research on how peri ocular tissue including the eye lids, lacrimal gland, trigeminal ganglia is affected by viral infections and their method of action. Authors can also submit manuscripts that detail the efficacy of drugs that are taken systemically or topically to reduce viral replication in eye, reduce post viral inflammation, whether standalone or in combination with existing drugs.
