Research Topic

Systems Biocatalysis for Bioprocess Design

About this Research Topic

Biocatalysis is of key importance for selective bioprocesses, both for renewable biosynthesis and biodegradation in nature as well as for numerous human activities and applications such as the production of target compounds from selected starting materials at laboratory small scale, pilot scale or industrial large scale or for a combination of both in biocatalytic conversions of biobased starting materials. Advances in bottom-up and top-down approaches and in understanding molecular and engineering aspects of bioprocesses have enabled tremendous achievements in fundamental and applied science and technology in numerous bioeconomy areas. Biocatalysis is a key enabling technology for bioprocess design and value creation in a sustainable bioeconomy.

The Research Topic Systems Biocatalysis for Bioprocess Design aims at bringing together advances and approaches from different molecular and engineering sciences, technologies and industrial applications in designing and scaling biocatalytic systems for preparing products. While we intend to keep the scope of this Special Issue broad in order to adequately reflect the diversity of research within Systems Biocatalysis, some areas of interest include: (i) approaches, methodologies and toolboxes for novel one-step enzyme-catalyzed reactions which reduce the number of reaction steps of existing routes, (ii) retrosynthetic analysis (iii) coupling of two or more enzymatic reactions or the coupling of chemical reactions with enzymatic reactions, (iv) separation in space of substrates, enzymes, products requiring different reaction environments, (v) design of multi-step enzyme-catalyzed reactions (vi) concepts of simultaneous or time-separated enzyme-catalyzed reactions, (vii) set-up of the connectivity and topology of enzyme-catalyzed reaction steps, (viii) biocatalytic total synthesis, (ix) biocatalytic reaction engineering, (x) product recovery. The goals of this Research Topic are, however, not limited to these ten areas of interest and potential authors are encouraged in outlining newly emerging areas for Systems Biocatalysis.

Themes covered in this Research Topic include but are not limited to:
• approaches, methodologies and toolboxes for novel one-step enzyme-catalyzed reactions which reduce the number of reaction steps of existing routes
• retrosynthetic analysis
• coupling of two or more enzymatic reactions or the coupling of chemical reactions with enzymatic reactions
• separation in space of substrates, enzymes, products requiring different reaction environments
• design of multi-step enzyme-catalyzed reactions
• concepts of simultaneous or time-separated enzyme-catalyzed reactions
• set-up of the connectivity and topology of enzyme-catalyzed reaction steps
• biocatalytic total synthesis
• biocatalytic reaction engineering
• product recovery


Keywords: Biocatalysis, Biotransformation, Biosynthesis, Total synthesis, Bioprocesses


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Biocatalysis is of key importance for selective bioprocesses, both for renewable biosynthesis and biodegradation in nature as well as for numerous human activities and applications such as the production of target compounds from selected starting materials at laboratory small scale, pilot scale or industrial large scale or for a combination of both in biocatalytic conversions of biobased starting materials. Advances in bottom-up and top-down approaches and in understanding molecular and engineering aspects of bioprocesses have enabled tremendous achievements in fundamental and applied science and technology in numerous bioeconomy areas. Biocatalysis is a key enabling technology for bioprocess design and value creation in a sustainable bioeconomy.

The Research Topic Systems Biocatalysis for Bioprocess Design aims at bringing together advances and approaches from different molecular and engineering sciences, technologies and industrial applications in designing and scaling biocatalytic systems for preparing products. While we intend to keep the scope of this Special Issue broad in order to adequately reflect the diversity of research within Systems Biocatalysis, some areas of interest include: (i) approaches, methodologies and toolboxes for novel one-step enzyme-catalyzed reactions which reduce the number of reaction steps of existing routes, (ii) retrosynthetic analysis (iii) coupling of two or more enzymatic reactions or the coupling of chemical reactions with enzymatic reactions, (iv) separation in space of substrates, enzymes, products requiring different reaction environments, (v) design of multi-step enzyme-catalyzed reactions (vi) concepts of simultaneous or time-separated enzyme-catalyzed reactions, (vii) set-up of the connectivity and topology of enzyme-catalyzed reaction steps, (viii) biocatalytic total synthesis, (ix) biocatalytic reaction engineering, (x) product recovery. The goals of this Research Topic are, however, not limited to these ten areas of interest and potential authors are encouraged in outlining newly emerging areas for Systems Biocatalysis.

Themes covered in this Research Topic include but are not limited to:
• approaches, methodologies and toolboxes for novel one-step enzyme-catalyzed reactions which reduce the number of reaction steps of existing routes
• retrosynthetic analysis
• coupling of two or more enzymatic reactions or the coupling of chemical reactions with enzymatic reactions
• separation in space of substrates, enzymes, products requiring different reaction environments
• design of multi-step enzyme-catalyzed reactions
• concepts of simultaneous or time-separated enzyme-catalyzed reactions
• set-up of the connectivity and topology of enzyme-catalyzed reaction steps
• biocatalytic total synthesis
• biocatalytic reaction engineering
• product recovery


Keywords: Biocatalysis, Biotransformation, Biosynthesis, Total synthesis, Bioprocesses


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

22 June 2021 Abstract
20 October 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

22 June 2021 Abstract
20 October 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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