The extracellular matrix (matrisome) is an essential component of the tumor microenvironment that provides extrinsic/intrinsic cues to regulate cellular processes such as proliferation, migration, invasion, adhesion, etc. Current frontline treatment strategies trigger re-modeling of the matrix and treatment response. Re-modeling of the matrisome’s spatiotemporal architecture facilitates metastatic progression, treatment resistance, and disease recurrence. Therefore, it is imperative to understand the biology of matrix deposition, environmental cues, and re-modeling during cancer dormancy, seeding, colonization, and metastatic niche development. Recent advances in high-throughput technologies and spatial biology have helped us to understand the real-time biology of tumor-matrix development and overcome therapeutic resistance. Matrisome signatures also provide predictive measurement to define tumoral-heterogeneity and tumor-matrix phenotype relationship.
This Research Topic aims to cover recent advances in matrix biology to understand the mechanism of tumor progression and its therapeutic development. Research studies defining the precise role of the matrix in cancer biology to develop prognostic, diagnostic and therapeutic approaches are encouraged.
We invite submissions of original research articles, brief reports, case reports, reviews and perspective insights focused on cancer matrisome biology and therapy. The research areas include, but are not limited, to:
• Deciphering the mechanistic pathways influencing matrix biology and drug response
• Discovery of matrisome related biomarkers used for prognostic, diagnostic and therapy
• Development of in vitro and in vivo preclinical and clinical models to study matrix modeling
• Targeting tumor-matrix biology using clinically relevant therapeutic models and devices in precision medicine
• Spatial-temporal kinetics of matrisome related signature and its therapeutic implementation
The extracellular matrix (matrisome) is an essential component of the tumor microenvironment that provides extrinsic/intrinsic cues to regulate cellular processes such as proliferation, migration, invasion, adhesion, etc. Current frontline treatment strategies trigger re-modeling of the matrix and treatment response. Re-modeling of the matrisome’s spatiotemporal architecture facilitates metastatic progression, treatment resistance, and disease recurrence. Therefore, it is imperative to understand the biology of matrix deposition, environmental cues, and re-modeling during cancer dormancy, seeding, colonization, and metastatic niche development. Recent advances in high-throughput technologies and spatial biology have helped us to understand the real-time biology of tumor-matrix development and overcome therapeutic resistance. Matrisome signatures also provide predictive measurement to define tumoral-heterogeneity and tumor-matrix phenotype relationship.
This Research Topic aims to cover recent advances in matrix biology to understand the mechanism of tumor progression and its therapeutic development. Research studies defining the precise role of the matrix in cancer biology to develop prognostic, diagnostic and therapeutic approaches are encouraged.
We invite submissions of original research articles, brief reports, case reports, reviews and perspective insights focused on cancer matrisome biology and therapy. The research areas include, but are not limited, to:
• Deciphering the mechanistic pathways influencing matrix biology and drug response
• Discovery of matrisome related biomarkers used for prognostic, diagnostic and therapy
• Development of in vitro and in vivo preclinical and clinical models to study matrix modeling
• Targeting tumor-matrix biology using clinically relevant therapeutic models and devices in precision medicine
• Spatial-temporal kinetics of matrisome related signature and its therapeutic implementation
