Current Aspects in Chemopreventive Strategies, Volume II

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Editorial

15 July 2022

Editorial: Current Aspects in Chemopreventive Strategies, Volume II

Hardeep Singh Tuli

,

Mükerrem Betül Yerer

and

Katrin Sak

1,284 views

1 citations

Editors

3

Hardeep Singh Tuli

Maharishi Markandeshwar University, Mullana

Mukerrem Betul Yerer Aycan

Erciyes University

Katrin Sak

Independent researcher

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This Research Topic is part of Current Aspects in Chemopreventive Strategies series: Current Aspects in Chemopreventive Strategies

Despite extensive studies, cancer remains one of the most dreadful diagnoses and biggest challenges for human health all over the world, representing a leading cause of death in the industrialized countries. Various chemotherapeutic drugs, such as Doxorubicin, Tamoxifen and Paclitaxel, have been used for the treatment of tumors for more than half a century; however, there are still no curative options currently available in clinical settings and the severe adverse effects of these drugs threaten the well-being of the patients seriously. Current evidence suggests that further knowledge is urgently needed to clarify the unknown properties and molecular mechanisms of action of various chemopreventive molecules. Such substances refer to the agents which are used for reducing the risk of carcinogenesis, or delaying development or recurrences of malignant disorders.

Several small molecules either of biological origin or from synthetic chemistry, such as cordycepin, mitomycin C, doxorubicin and methotrexate, have demonstrated great efficacy towards a variety of cancers. These agents are found to suppress the proliferation of cancer cells by various mechanisms such as apoptotic cell death, cancer cell cycle arrest, inhibition of angiogenesis and metastasis, induction of ROS generation etc. Few in silico tools, such as docking and QSAR (Quantitative structure-activity relationship) techniques, can be used to retrieve more comprehensive information about the targets and the action mechanisms of such molecules. However, there has been a vigorous need to explore the acute as well as the chronic toxicological effects of such chemopreventive molecules for further clinical implementation against diseases.

This Research Topic aims to highlight the ongoing advancement in chemopreventive and therapeutical approaches, as well as the promising role of the above mentioned agents in the context of cancer prevention and therapy. In particular, the specific objective of this collection is to gather the results of well-designed in silico, in vitro and ,in vivo preclinical studies, in addition to randomized double blind multi-centred clinical trials designed to decrease the adverse actions of these drugs and to draw scientists’ attention towards precision and personalized medicine in cancer patients by performing targeted therapies. The present Research Topic welcomes high-quality Original Research as well as Review articles providing:
• Strategies for cancer chemoprevention using natural medicine;
• Synergistic effects of chemopreventive agents with existing chemotherapeutic drugs.

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Editors

Hardeep Singh Tuli

Maharishi Markandeshwar University, Mullana

Mukerrem Betul Yerer Aycan

Erciyes University

Katrin Sak

Independent researcher

Impact

91,518 Total views

67,013 Article views

22,807 Article downloads

1,698 Topic views

Published In

Frontiers in Pharmacology

Pharmacology of Anti-Cancer Drugs

Frontiers in Oncology

Pharmacology of Anti-Cancer Drugs

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