Inflammatory arthritis affects 1-2% of the population and may be progressive and erosive resulting in disability. Autoantibodies are now routinely used in the diagnosis, however many patients are negative. Disease endotypes with similar clinical manifestations but potentially different pathophysiology may respond to different therapies. Profiling synovial tissue immune cell populations including B cells, T cells, macrophages and fibroblasts along with gene expression analysis has shown specific abnormalities that may reflect underlying immunological mechanisms and inform a treat to target approach.
The synovial membrane (SM) is the target tissue of the joints in patients with inflammatory arthritis (IA). Analysis of the SM has provided valuable insights into our current understanding of pathological processes and treatment responses in IA. Synovial biopsies may be obtained using arthroscopic or imaging techniques, however novel state-of-the-art techniques of SM analyses now allow detailed assessment of cellular and molecular pathways to inform a more complete understanding of the immunopathogenesis and provide a new approach to precision medicine using targeted of biologic therapies.
Accordingly, this Research Topic would like to focus on the following themes for submission:
• Cellular and molecular pathways in synovial tissue
• Fibroblasts Macrophages
• Lymphocytes Cytokines
• Immunometabolism
• Signalling Autoantibodies
Inflammatory arthritis affects 1-2% of the population and may be progressive and erosive resulting in disability. Autoantibodies are now routinely used in the diagnosis, however many patients are negative. Disease endotypes with similar clinical manifestations but potentially different pathophysiology may respond to different therapies. Profiling synovial tissue immune cell populations including B cells, T cells, macrophages and fibroblasts along with gene expression analysis has shown specific abnormalities that may reflect underlying immunological mechanisms and inform a treat to target approach.
The synovial membrane (SM) is the target tissue of the joints in patients with inflammatory arthritis (IA). Analysis of the SM has provided valuable insights into our current understanding of pathological processes and treatment responses in IA. Synovial biopsies may be obtained using arthroscopic or imaging techniques, however novel state-of-the-art techniques of SM analyses now allow detailed assessment of cellular and molecular pathways to inform a more complete understanding of the immunopathogenesis and provide a new approach to precision medicine using targeted of biologic therapies.
Accordingly, this Research Topic would like to focus on the following themes for submission:
• Cellular and molecular pathways in synovial tissue
• Fibroblasts Macrophages
• Lymphocytes Cytokines
• Immunometabolism
• Signalling Autoantibodies
