About this Research Topic
With the development of crystallography and electron microscopy, the immune recognition of the antigens from pathogens and tumors and the immune modulation process are becoming crystal clear and the related immune interventions are applied in disease control and therapy. The increasing detailed and systematic knowledge on peptide presentation of MHC molecules and the TCR recognition paves ways for the TCR-T based immune therapy on tumors and chronic infectious diseases, and also promotes the progress of peptide-based universal vaccines. Antigen-antibody interaction-orientated monoclonal antibody construction and dominant/conserved epitope identification are broadly used within the emergency medicine for emerging and re-emerging infectious diseases, such as COVID-19 and Ebola. Meanwhile, the immune check-point based cancer therapy has also benefited from the illumination of molecular mechanism of immune recognition and regulations, e.g. anti-PD-1 and 4-1BB biologics, etc. However, plenty of questions still remain unexploited from the basic research to the clinical applications.
The goal of this Research Topic is to provide a forum to advance research on the molecular bases of the MHC presentation, TCR recognition, and antibody neutralization of tumor and emerging and re-emerging pathogen-derived antigens and related immunoregulatory molecules, as well as to explore structure-oriented biologic interventions in the attempt to achieve rapid and precision medicine development for these diseases. We welcome submissions of Original Research, Review and Mini Review on the subtopics below:
• Molecular mechanism of antigen presentation of MHC molecules;
• TCR recognition of MHC/peptide complexes;
• Structures of receptor-binding proteins of viruses and their cell receptors (e.g. coronaviruses, influenza viruses etc.);
• Molecular mechanism of monoclonal antibody neutralization of pathogens;
• Interaction of immunoregulatory molecules and their ligands or receptors;
• Structural bases of immune interventions targeting immune recognition and regulation;
• Molecular bases for immune escape of pathogens and tumors;
• Structural bases for immune evolution of animals by the pressure of pathogens.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.