Pituitary adenoma accounts for about 12% of intracranial tumors. Most of the pituitary adenoma are benign and middle-aged. Pituitary tumors are very complex and heterogeneous and have a very wide range of proliferative and aggressive behaviors, and how to define and classify these tumors remains controversial. Recently, pituitary tumors have been investigated in large scale (exome and genome) molecular analyses (transcriptome microarrays and sequencing), to uncover novel markers and therapeutic targets. The molecular diagnosis and imaging diagnosis of pituitary tumors have been greatly improved. Meanwhile, there has been an unprecedented expansion in the development of new agents for the treatment of pituitary tumors.
This Research Topic will discuss the recent advances in pituitary tumor research, including molecular diagnosis, imaging diagnosis, pathogenic mechanism, tumorigenic mechanism, and clinical management. Overall, large-scale molecular studies from bioinformatics analysis to in vivo and in vitro experimental analysis would provide key insight into the molecular mechanisms behind pituitary adenoma pathogenesis, highlighting previously reported molecular markers, bringing new candidates into the research field, and reapplying traditional perspectives to newly discovered molecular mechanisms. Early identification of patients with pituitary adenoma through recognition and increased awareness of the definition of pituitary adenoma will encourage the early use of aggressive therapeutic strategies.
We welcome authors to submit Original Research Articles, Review Articles, and Opinion Articles to clarify the recent advances in pituitary tumor research.
Potential topics include, but are not limited to:
1. Excavation of critical, prognosis associated biomarkers like genes or metabolites involved in the tumorigenic mechanisms of pituitary tumor
2. Diagnostic markers or models with experimental validation on the feature genes
3. Prognostic markers or models with experimental validation on the feature genes
4. Improvement in the imaging diagnosis of pituitary tumor
5. Novel molecular subtypes of pituitary tumor based on large-scale bioinformatics analysis with external validation
6. All types of pituitary tumor, including functional and nonfunctional pituitary adenomas, invasive and noninvasive pituitary adenomas
7. Pituitary adenoma during childhood and adolescence
8. Pituitary adenocarcinoma
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Pituitary adenoma accounts for about 12% of intracranial tumors. Most of the pituitary adenoma are benign and middle-aged. Pituitary tumors are very complex and heterogeneous and have a very wide range of proliferative and aggressive behaviors, and how to define and classify these tumors remains controversial. Recently, pituitary tumors have been investigated in large scale (exome and genome) molecular analyses (transcriptome microarrays and sequencing), to uncover novel markers and therapeutic targets. The molecular diagnosis and imaging diagnosis of pituitary tumors have been greatly improved. Meanwhile, there has been an unprecedented expansion in the development of new agents for the treatment of pituitary tumors.
This Research Topic will discuss the recent advances in pituitary tumor research, including molecular diagnosis, imaging diagnosis, pathogenic mechanism, tumorigenic mechanism, and clinical management. Overall, large-scale molecular studies from bioinformatics analysis to in vivo and in vitro experimental analysis would provide key insight into the molecular mechanisms behind pituitary adenoma pathogenesis, highlighting previously reported molecular markers, bringing new candidates into the research field, and reapplying traditional perspectives to newly discovered molecular mechanisms. Early identification of patients with pituitary adenoma through recognition and increased awareness of the definition of pituitary adenoma will encourage the early use of aggressive therapeutic strategies.
We welcome authors to submit Original Research Articles, Review Articles, and Opinion Articles to clarify the recent advances in pituitary tumor research.
Potential topics include, but are not limited to:
1. Excavation of critical, prognosis associated biomarkers like genes or metabolites involved in the tumorigenic mechanisms of pituitary tumor
2. Diagnostic markers or models with experimental validation on the feature genes
3. Prognostic markers or models with experimental validation on the feature genes
4. Improvement in the imaging diagnosis of pituitary tumor
5. Novel molecular subtypes of pituitary tumor based on large-scale bioinformatics analysis with external validation
6. All types of pituitary tumor, including functional and nonfunctional pituitary adenomas, invasive and noninvasive pituitary adenomas
7. Pituitary adenoma during childhood and adolescence
8. Pituitary adenocarcinoma
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
