Research Topic

Non-coding RNAs in Neurodevelopmental Disorders

  • Submission closed.

About this Research Topic

The human genome mostly consists of DNA that does not encode for protein. Although originally thought to represent evolutionary ‘junk,’ it has been shown that much of the junk DNA in the human genome is actively transcribed to RNA in a highly regulated, tissue-specific manner. Following this insight, ...

The human genome mostly consists of DNA that does not encode for protein. Although originally thought to represent evolutionary ‘junk,’ it has been shown that much of the junk DNA in the human genome is actively transcribed to RNA in a highly regulated, tissue-specific manner. Following this insight, non-coding RNAs (ncRNAs) were demonstrated to be fundamental to many intracellular processes, such as targeting transcription factors to their binding sites, initiating chromatin remodeling, blocking transcription or translation of other genes both in cis and trans, and a variety of other functions that are still being uncovered. Perhaps not surprisingly, studies quickly followed showing that disruption of ncRNA biogenesis can lead to molecular and cellular defects. Recently, ncRNAs have been demonstrated to be abnormal in the brains of patients with common neurodevelopmental disorders and their animal models, such as autism, schizophrenia, and bipolar disorder. These diseases were previously known to have a significant hereditary component, but their genomic etiology is complex and has remained poorly understood. Emerging research into underlying ncRNA problems in these disorders has the potential to reconcile their known heritability with their genomic and phenotypic heterogeneity, and hopefully unveil novel genomic pathologic mechanisms that can ultimately lead to new molecular therapeutics. In this Research Topic, we will present a broad array of reviews and new findings in this emerging and critically important area of neurosciences research.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top