About this Research Topic
Epidemiologic evidences indicate an increasing incidence of kidney diseases which has been recognized as a leading global health concern. However, the reasons behind the increase in kidney disease cases remains vague. Several factors such as genetic mutations, dysfunction of different kidney cell types, kidney microenvironment, inflammation, nephrotoxins, acute kidney injury and dietary interventions significantly contribute to the end stage kidney diseases, together with other clinical manifestations such as hypertension, diabetes, myocardial infarction and glomerulonephritis. Understanding the primary causes and mechanisms leading to kidney disease progression is essential for the prognosis and treatment of this class of diseases. Using genetic, single cell RNA sequencing and metabolomics approaches, novel findings are emerging which indicate a critical role of new genetic, cellular and molecular targets in kidney disease progression that deserve to be investigated in detail.
The goal of this Research Topic is to provide new genetic, cellular and molecular insight in the diagnosis and treatment of different types of kidney diseases, such as polycystic kidney disease (PKD), acute kidney injury (AKI), chronic kidney disease (CKD) and AKI to CKD transition. The Research Topic also focuses on the role of early life stressors in kidney disease progression and kidney disease of unknown etiology. Furthermore, we aim to summarize recent developments in our understanding of the role of different factors in pathophysiology of kidney diseases and their implementation in clinical and therapeutic approaches.
We will consider original research, brief reports and review articles covering the following themes:
1. Identification of novel genes and their impact on pathophysiology of kidney diseases
2. Novel findings exploring the role of kidney cell specific genetic and molecular alterations in the regulation of microenvironment and progression of kidney diseases
3. Molecular basis of vascular dysfunction and other kidney injury risk factors on renal disorder
4. Environmental stress induced genetic/epigenetic alterations and their impact on progression of kidney diseases/ early onset of chronic kidney diseases.
5. Recent development in therapeutic approaches to treat kidney patients.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.