Research Topic Highlights
The article collection addresses critical aspects of immunological aging, emphasizing changes in adaptive immune mechanisms, lymphoid tissue functionality, and susceptibility to infections. Key topics include lysosomal biology in adaptive immunity, highlighting lysosomal dysfunction's impact on T cell metabolism and aging; age-related alterations in pulmonary immunity linked with tissue-specific oxidative stress, inflammation, and potential intervention strategies; impaired lymph node architecture and stromal cell functionality affecting naïve T-cell survival and mobility; and sex-specific differences influencing vaccine responses and infection susceptibility in older adults, particularly regarding influenza and COVID-19 vaccines. Collectively, the studies underline vital connections between age-related tissue remodeling, metabolic signaling, sex differences, and adaptive immune decline, suggesting targeted therapeutic approaches to enhance immunological resilience and vaccine responsiveness in the elderly.
Context and Scope
We are delighted to present the “Horizons in Aging, Immune System and Infectious Diseases” article collection. This collection showcases high-impact, authoritative and reader-friendly mini-review articles authored by leaders in the aging and immunity field covering important topics at the forefront of the aging, immunity and infectious diseases field.
The cutting-edge work presented in this article collection highlights important progress (conceptual or technical) in the study of aging and immunity that has been impactful for the field, as well as important areas that need to be addressed in the future.
Contributions are by invitations only and new articles will be added to this collection as they are published.
Research Topic Highlights
The article collection addresses critical aspects of immunological aging, emphasizing changes in adaptive immune mechanisms, lymphoid tissue functionality, and susceptibility to infections. Key topics include lysosomal biology in adaptive immunity, highlighting lysosomal dysfunction's impact on T cell metabolism and aging; age-related alterations in pulmonary immunity linked with tissue-specific oxidative stress, inflammation, and potential intervention strategies; impaired lymph node architecture and stromal cell functionality affecting naïve T-cell survival and mobility; and sex-specific differences influencing vaccine responses and infection susceptibility in older adults, particularly regarding influenza and COVID-19 vaccines. Collectively, the studies underline vital connections between age-related tissue remodeling, metabolic signaling, sex differences, and adaptive immune decline, suggesting targeted therapeutic approaches to enhance immunological resilience and vaccine responsiveness in the elderly.
Context and Scope
We are delighted to present the “Horizons in Aging, Immune System and Infectious Diseases” article collection. This collection showcases high-impact, authoritative and reader-friendly mini-review articles authored by leaders in the aging and immunity field covering important topics at the forefront of the aging, immunity and infectious diseases field.
The cutting-edge work presented in this article collection highlights important progress (conceptual or technical) in the study of aging and immunity that has been impactful for the field, as well as important areas that need to be addressed in the future.
Contributions are by invitations only and new articles will be added to this collection as they are published.
