About this Research Topic
The Wingless‐related integration site (Wnt) signaling pathways have been associated with various physiological processes, such as embryonic development, growth, and maintenance of tissues. These ligands are also involved in pathophysiological events, notably tumorigenesis, osteo-articular and endocrine disorders. Indeed, Wnt signaling has been involved in the metabolic reprogramming of cancer cells, and altered Wnt signaling is seen leading to metabolic alterations of cell physiology, including glycolysis and lipogenesis. Moreover, studies revealed that Wnt signaling is implicated in the function of endocrine organs, such pancreatic β-cell function, and adrenal physiology, as well as in some endocrine disorders, like type II diabetes.
The goal of the present research topic is to assemble the current knowledge and current research performed on the influence of Wnt signaling in endocrine and metabolic disorders. As Wnt signaling is heavily involved in these disorders, the interest of a better understanding of Wnt signaling pathways, to possibly fine-tune them, seems highly relevant in the perspective of investigating on future potential therapeutics. Focusing on the regulation of Wnt signaling pathways in cell metabolism and in mitochondrial activity is particularly promising for controlling tumor growth.
The scope is to highlight the role of Wnt ligands and Frizzled receptors, as well as Wnt modulators (DKKs, sFRPs, etc…) in these disorders, and to characterize molecular pathways triggered during Wnt signaling in this context (beta-catenin, calcium-dependent, planar cell polarity…).
Particular attention will be given to articles studying the influence of Wnt signaling on cell metabolism and on research investigating the cross-talk of Wnt signaling pathways with other signaling pathways involved in endocrine disorders (MAPK, PI3K-Akt, AMPK, HIF, Notch…).
This topic will welcome both research and review articles.
Keywords: Wnt, Metabolism, pathophysiology, crosstalk, signaling
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