About this Research Topic
This Research Topic aims to provide an overview of the progress made in the field of JAK inhibition and JAK/STAT agonism (cytokine-based modalities) for the treatment of autoimmune and inflammatory diseases.
The role of JAK isoforms pairing in type 1 and type 2 cytokine receptors signaling has been well characterized but the relative contribution of each one of the two JAK isoforms to the signaling output of various cytokine receptors is poorly understood. In this regard, a better understanding of JAK isoform selective inhibition and the relative clinical consequences will be an important aspect to optimize their clinical utility.
We seek Original Research, Review, Perspective and Clinical Trial manuscripts that cover, but are not limited to, the following aspects of the mechanistic and therapeutic effects of inhibiting JAK/STAT signaling or modulate a specific cytokine receptor with a therapeutic agent:
• Mechanistic studies of JAK inhibition
• New clinical characterization of JAK inhibitors
• New technologies and/or biomarkers that could be utilized to optimize the use of JAK inhibitors or predict their efficacy
• Novel approaches to modulate cytokine receptor signaling
Dr. Jean-Baptiste Telliez is an employee of Pfizer Inc, investigating JAK inhibition therapeutics. Dr. Olli Silvennoinen is co-founder of Ajax therapeutics, involved in the development of JAK inhibitors for cancer therapy.
Keywords: Cytokines, JAK, Autoimmunity, Inflammation, Kinase Inhibitors, molecular regulation of JAK kinases, structure of JAK kinases, JAK inhibitors
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