Research Topic

Improving the safety of cell therapy products by suicide gene transfer

  • Submission closed.

About this Research Topic

The gene transfer of a suicide gene, such as the herpes simplex virus thymidine kinase (HSV-tk) was initially intended to target and destroy tumor cells, taking advantage of its bystander effect to kill gene-modified and non modified tumor cells. The suicide gene transfer was used later as a safety system in ...

The gene transfer of a suicide gene, such as the herpes simplex virus thymidine kinase (HSV-tk) was initially intended to target and destroy tumor cells, taking advantage of its bystander effect to kill gene-modified and non modified tumor cells. The suicide gene transfer was used later as a safety system in order to control the alloreactivity of donor lymphocytes infused as a cell therapy product after hematopoietic cell transplantation. With increasing safety concerns related to the use of ex vivo expanded stem cells or induced progenitor cells, the prior gene transfer of a suicide gene in cell therapy products becomes an emerging approach to secure the product in case of in vivo oncogenic transformation.

This Frontiers in Research Topic is aimed at presenting the suicide gene approach as a safety system for cell therapy products, with especially:
(1) the different suicide gene systems available to date, based, as an example, on the use of prodrug-converting enzymes or the expression of targets of monoclonal antibodies or controllable inducers of apoptosis, with their respective advantages
(2) the methods and vectors used to introduce the suicide gene in target cells
(3) the limits of the use of suicide genes, such as mechanisms of resistance to the prodrugs, immune responses toward gene-modified cells…
(4) the monitoring of suicide gene-modified cells and the possibility to image them in vivo

This Topic will not be restricted to T cells, for which a large set of data have been published, and will also address other type of cell therapy products.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top