Research Topic

New Therapies in the Treatment of Sarcomas

About this Research Topic

Bone sarcomas, especially osteosarcoma and Ewing sarcoma, are primary bone tumors mainly affecting children and young adults. Current treatment did not progress for the last 40 years and, is based on a multimodal therapy including neo-adjuvant chemotherapy, surgical resection, and radiotherapy in some cases. With these therapeutic options, the survival rate reaches 60-70% for the localized forms but drastically drops down to 25-30% for the bad responders to treatment or for patients with metastasis at the diagnosis. The unsatisfactory outcomes and side effects associated with the current chemotherapy underscore the urgent need to find new therapeutic approaches for osteosarcoma and Ewing sarcoma. In this context, a better knowledge of bone biology has become essential for the medical and cancer research communities. This article collection aims to provide the most recent data on primary bone cancers development including genomic and proteomic analyses, clinical analyses, as well as future directions for new therapies and clinical trials for these pediatric tumors.

Potential topics include:
• Epigenomic, genomic and proteomic analysis in the development of primary bone tumors
• Cellular and molecular mechanisms underlying primary bone tumors
• Clinical analysis (histopathology and imaging) in primary bone tumors
• Importance of bone microenvironment (bone cells, immune cells…) to support development and progression of primary bone tumors
• Resistance to treatment and future horizons in treatments of primary bone tumors

We welcome contributions of different types of articles including original research articles, hypotheses, and theory, as well as reviews and mini-reviews.


Keywords: osteosarcoma, Ewig sarcoma, pediatric tumors, primary bone tumors


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Bone sarcomas, especially osteosarcoma and Ewing sarcoma, are primary bone tumors mainly affecting children and young adults. Current treatment did not progress for the last 40 years and, is based on a multimodal therapy including neo-adjuvant chemotherapy, surgical resection, and radiotherapy in some cases. With these therapeutic options, the survival rate reaches 60-70% for the localized forms but drastically drops down to 25-30% for the bad responders to treatment or for patients with metastasis at the diagnosis. The unsatisfactory outcomes and side effects associated with the current chemotherapy underscore the urgent need to find new therapeutic approaches for osteosarcoma and Ewing sarcoma. In this context, a better knowledge of bone biology has become essential for the medical and cancer research communities. This article collection aims to provide the most recent data on primary bone cancers development including genomic and proteomic analyses, clinical analyses, as well as future directions for new therapies and clinical trials for these pediatric tumors.

Potential topics include:
• Epigenomic, genomic and proteomic analysis in the development of primary bone tumors
• Cellular and molecular mechanisms underlying primary bone tumors
• Clinical analysis (histopathology and imaging) in primary bone tumors
• Importance of bone microenvironment (bone cells, immune cells…) to support development and progression of primary bone tumors
• Resistance to treatment and future horizons in treatments of primary bone tumors

We welcome contributions of different types of articles including original research articles, hypotheses, and theory, as well as reviews and mini-reviews.


Keywords: osteosarcoma, Ewig sarcoma, pediatric tumors, primary bone tumors


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

17 August 2021 Abstract
15 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

17 August 2021 Abstract
15 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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