About this Research Topic
The complexity of tumor microenvironment makes the treatment of cancer, especially advanced cancer, extremely challenging. Surgery, chemotherapy, and radiation therapy are still the main treatment methods, but each method has its limitations and risks. Nanomaterials can combine multiple treatment methods according to the characteristics of tumor tissue microenvironment to greatly improve the effect of cancer treatment. For example, nanomaterials can improve the oxygen content of tumor sites by improving blood supply, delivering oxygen carriers, catalysing endogenous hydrogen peroxide and other ways, thus reshaping the tumor hypoxic microenvironment. Reducing hypoxia may have sensitizing effects on radiotherapy, chemotherapy, phototherapy, acoustic therapy and so on. In addition, nanomaterials combined with chemotherapeutic drugs can can induce deleterious oxidative stress in tumor sites, consume GSH and other antioxidant substances to alter cell REDOX homeostasis and achieve anti-tumor effect. Multimodal strategies for tumor diagnosis and treatment based on nanomaterials and nanotechnology represent highly relevant challenges for the future of anticancer treament.
This Research Topic aims at presenting the trend and recent advances on nanomaterials targeting the tumor microenvironment for cancer diagnosis and therapy.
We welcome Original Article, Review and Mini Review in the subtopics of interest, which include, but not limited to the subtopics below:
1) Mechanisms and regulation of drug delivery by nanomaterials to the tumor microenvironment
2) Drug-loaded nanomaterials for cancer chemosensitization
3) Overcoming of radiotherapy tolerance with nanomaterials
4) Multimodal nanomaterial system for cancer diagnosis and treatment
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: Nanomaterials, Tumor microenvironment, Multimodal therapy, Drug delivery, Diagnosis and Treatment of Cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.